急性脑梗死患者血清炎性因子、t-PA、PAI-1变化规律及其意义

The levels of inflammatory factors of t-PA and PAI-1 in serum and its significance in patients with acute cerebral infarction

目的探讨急性脑梗死患者血清炎性因子、组织型纤溶酶原激活物(t-PA)及快速抑制酶(PAI-1)的变化规律及其与预后的关系。方法选取急性脑梗死患者100例作为观察组,同期非急性脑梗死患者100例作为对照组,检测观察组患者在入院时、入院后不同时间的血清炎性因子、t-PA、PAI-1水平变化规律,并分析其与患者脑梗死面积、预后的关系。结果观察组患者入院时及入院后第3、7、14天的IL-6、IL-18、PAI-1及CRP水平均高于对照组(P<0.05),而t-PA水平均低于对照组(P<0.05);观察组IL-6、IL-8、PAI及CRP水平在入院后呈逐步降低趋势与入院时比较差异有统计学意义(P<0.05),而T-PA水平入院后第3、7天较入院时降低(P<0.05),在入院后第14天较入院时升高(P<0.05)。血清IL-6、IL-8、PAI-1及CRP水平比较:大梗死亚组>中梗死亚组>小梗死亚组(P<0.05);中梗死亚组预后不良亚组>预后良好亚组;血清t-PA水平比较:大梗死亚组<梗死亚组(P<0.05),预后不良亚组<预后良好亚组(P<0.05)。结论急性脑梗死患者的IL-6、IL-18、PAI-1、t-PA及CRP水平较非脑梗死患者有显著差异,同时与患者的预后、梗死面积具有一定的关系。

Objective To investigate the acute cerebral infarction serum inflammatory factor , tissue type plasminogen activator（ t-PA） and rapid inhibition of the variation of the enzyme （ PAI1-） and relationship with prognosis .Methods Se-lected 100 cases of patients with acute cerebral infarction as the observation group , 100 cases of patients without acute cerebral infarction as control group .Changes of serum inflammatory factor , t-PA , PAI-1 were observed at different time of admission , after admission, and analyze its relationship with and prognosis of patients with cerebral infarction .Results The observation group patients’ IL-6 and IL-18, PAI-1 and CRP levels when admitted to hospital and 3, 7, 14 days after admission were higher than that of the control group （ P 〈0.05）, and t-PA levels were lower than the control group （ P 〈0.05）; observation group’s IL-6 and IL1-8, PAI-1, CRP levels on admission showed a gradual decreasing trend and showed statistically signifi -cant difference with at beginning of admission （ P 〈0.05 ） , and t-PA level after 3 and 7 days of admission were decreased （P 〈0.05）, after 14 days of admission, it increased than at the beginning of the admission （ P 〈0.05）.And serum IL-6, IL-8, and PAI-1 and CRP levels’ comparison：large infarction subgroup 〉median infarction subgroup 〉small infarction sub-group （ P 〈0.05）;adverse prognosis subgroup 〉good prognosis subgroup;serum t-PA levels：large infarction subgroup 〈median infarction subgroup 〈small infarction subgroup （ P 〈0.05）, adverse prognosis subgroup 〈good prognosis subgroup （ P 〈0.05）.Concluison There were significant differences of IL-6, IL-18, PAI-1,and t-PA and CRP levels in patients with acute cerebral infarction and patients without cerebral infarction , acute cerebral infarction has certain relationship with prognosis of patients and infarct area.