小剂量红霉素对慢性阻塞性肺疾病稳定期患者免疫功能的干预研究

Intervention low-dose erythromycin chronic obstructive pulmonary disease in patients with stable immune function

目的探讨小剂量红霉素对慢性阻塞性肺疾病(COPD)稳定期患者免疫功能的干预效果。方法选取COPD稳定期患者86例,分为观察组和对照组,每组各43例。观察组在对照组常规治疗的基础上加用小剂量红霉素治疗3个月。结果观察组患者治疗后的6 min步行距离(6MWD)、第1 s用力呼气容积(FEV1)和CD3+、CD4+、CD4+/CD8+以及Ig A、Ig G明显高于对照组,呼吸困难量表(m MRC)、CD8+和C反应蛋白(CRP)明显低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的6MWD、FEV1和CD3+、CD4+、CD4+/CD8+以及Ig A、Ig G明显高于治疗前,m MRC、CD8+和CRP明显低于治疗前,差异有统计学意义(P<0.05)。结论 COPD患者长期使用小剂量红霉素,可增强其免疫功能,改善其临床症状、肺功能及运动耐力。

Objective To investigate the effects of low-dose erythromycin stable immune function in stable chronic obstructive pulmonary disease（ COPD） patients. Methods Selected patients with stable COPD86 cases divided into observation group and the control group 43 cases. On the basis of the control group were observed conventional treatment group were treated with low-dose erythromycin treatment three months. Results6 minute walk test（ 6MWD） observation group after treatment,FEV1 and CD3^＋,CD4^＋,CD4^＋/ CD8＋and Ig A,Ig G was significantly higher,modified medical british research council（ m MRC）,CD8＋and C-reactive protein（ CRP） was significantly lower than the control group,the difference was statistically significant（ P〈0. 05）; 6MWD was observed in patients after treatment,FEV1 and CD3^＋,CD4^＋,CD4^＋/ CD8＋and Ig A,Ig G was significantly higher than before treatment,m MRC,CD8^＋and CRP was significantly lower than before treatment,the difference was statistically significant（ P〈0. 05）. Conclusion Long-term low-dose erythromycin,can be adjusted with COPD patients with stable immune function,improve lung function,symptoms and exercise tolerance.