血清白介素-6、干扰素-γ在慢性阻塞性肺疾病中的表达及临床意义

Expression and clinical significance of serum interleukin-6, interferon-γ in chronic obstructive pulmonary disease

目的探讨白介素-6(IL-6)、干扰素-γ(IFN-γ)在慢性阻塞性肺疾病(COPD)患者血清中的表达以及临床意义。方法选择2012年5月至2014年5月我院呼吸内科收治的132例COPD患者,分为COPD稳定组及急性加重期COPD组(AECOPD),并于同一时期随机选取100例健康体检者作为对照组,采用酶联免疫吸附法测定三组患者血清中的IL-6及IFN-γ水平。结果三组患者血清IL-6、IFN-γ水平经方差分析比较,差异有统计学意义(P<0.05),AECOPD组血清IL-6、IFN-γ水平高于COPD稳定组、对照组,COPD组血清IL-6、IFN-γ水平高于对照组。AECOPD组血清IL-6与IFN-γ呈正相关性(rs=0.702,P<0.05),COPD稳定期组中血清IL-6与IFN-γ呈正相关性(rs=0.618,P<0.05)。结论 IL-6、IFN-γ参与了COPD的发生及发展过程,因此可作为评估COPD病情的重要指标之一,临床有重要的参考价值。

Objective To explore the expression and clinical significance of interleukin-6（ IL-6）,interferon-γ（ IFN-γ） in chronic obstructive pulmonary disease（ COPD）. Methods A total of 132 cases with COPD in our respiratory department from 2012 May to 2014 May were divided into COPD group and acute exacerbation COPD（ COPD group） according to progress of disease,at the same time,100 healthy people as control group were randomly selected. The serum IL-6 and IFN-γ level in three groups were measured by enzyme linked immunosorbent assay（ ELISA）. Results Comparisons of serum IL-6,IFN-γ in three groups were conducted by variance analysis,the difference was statistically significant（ P〈0. 05）,in which serum IL-6 and IFN-γ in AECOPD group were higher than those in COPD group and control group,serum IL-6 and IFN-γ in COPD group were higher than those in control group. There was a positive correlation between serum IL-6and IFN-γ among AECOPD group（ r = 0. 702,P〈0. 05）,and there was a positive correlation between serum IL-6 and IFN-γ among COPD group（ r = 0. 618,P〈0. 05）. Conclusions Serum IL-6 and IFN-γ is involved in the occurrence and development process of COPD and it can be one of important indicators to evaluate state of COPD. It has an important reference value in clinical.