摘要
由苯甲醛在维生素B1作催化剂及碱性条件下进行安息香缩合得到安息香,然后在酸性条件下用三氯化铁氧化安息香制取二苯乙二酮,二苯乙二酮与尿素在碱性条件下反应得到苯妥英,再由苯妥英与氢氧化钠反应成盐得到苯妥英钠。
Benzoin was synthesized by benzaldehyde in alkaline condition under the catalysis of VB1. 1, 2-diphenyl ethanedione was prepared through oxidation of benzoin in acid condition using ferric chloride. 1, 2-diphenyl ethanedione reacted with urea via intramolecular cyclization reaction to obtain phenytoin. Sodium phenytoin was synthesized through reaction of phenytoin and sodium hydroxide.
出处
《浙江化工》
CAS
2015年第8期23-25,共3页
Zhejiang Chemical Industry
基金
河南省科技厅基础与前沿项目(142300410104)
河南省高等教育教学改革项目(2014SJGLX319)
河南省教育厅自然科学项目(14A150056)
关键词
苯妥英钠
二苯乙二酮
安息香
苯甲醛
合成
sodium phenytoin
1, 2-diphenyl ethanedione
benzoin
benzaldehyde
synthesis
