肺表面活性物质联合机械通气治疗足月新生儿呼吸窘迫综合征的临床观察

Pulmonary surfactant combined with mechanical ventilation for term neonates with respiratory distress syndrome

目的 探讨肺表面活性物质联合机械通气治疗足月新生儿呼吸窘迫综合征临床效果.方法 选取2013年3月至2014年8月我院儿科收治60例呼吸窘迫综合征足月新生儿随机分为观察组和对照组,对照组采用肺表面活性物质治疗,观察组在对照组基础上联合机械通气治疗,比较两组新生儿治疗效果及治疗前、治疗后1h、24 h PaO2、PaCO2及pH值.结果 观察组患儿治疗总有效率为96.66％明显高于对照组总有效率83.33％,两组比较差异有统计学意义（P＜0.05）;观察组患儿治疗1h及24 h后PaO2、pH值明显高于对照组,PaCO2值明显低于对照组,两组间各值比较有差异统计学意义（P＜0.05）.结论 肺表面活性物质联合机械通气治疗足月新生儿呼吸窘迫综合征可改善患儿PaO2、PaCO2及pH值,具有显著临床治疗效果,值得在临床中推广应用.

Objective To investigate the clinical effect of pulmonary surfactant combined mechanical ventilation for term neonates with respiratory distress syndrome.Methods 60 term newborns with respiratory distress syndrome admitted into our department from March,2013 to August,2014 were selected and were randomly divided into an observation group and a control group.The control group were treated with pulmonary surfactant;in addition,the observation group with mechanical ventilation.The treatment effect and the PaO2,PaCO2,and pH value before and 1 and 24 hours after the treatment were compared between these two groups.Results The total efficacy was 96.66% in the observation group and was 83.33% in the control group,with a statistical difference（P〈0.05）.1 and 24 hours after the treatment,the PaO2 level and pH value were significantly higher and the PaCO2 level was significantly lower in the observation group than in the control group,with statistical differences（P〈0.05）.Conclusions Pulmonary surfactant combined with mechanical ventilation for term newborns with respiratory distress syndrome can improve PaO2,PaCO2,and PH value,has significant clinical effect,and is worth being clinically generalized.