摘要
目的比较度洛西汀与氟西汀治疗伴躯体疼痛症状的抑郁症的疗效及安全性。方法选取2013年8月-2014年8月医院收治的抑郁症伴躯体疼痛症状的患者72例。随机分为度洛西汀组和氟西汀组各36例,治疗8周。用汉密顿抑郁量表(HAMD)、疼痛量表(MOSPM)和不良反应量表(TESS)评定疗效及不良反应。结果治疗8周后2组HAMD、MOSPM评分较治疗前显著下降(P<0.01),度洛西汀组MOSPM总分较氟西汀组下降更显著(P<0.05),2组不良反应差异无统计学意义(P>0.05)。结论度洛西汀与氟西汀治疗伴疼痛症状的抑郁症均有效,但以度洛西汀疗效更好。
Objective To compare the efficacy and safety of duloxetine and fluoxetine in the treatment of depression with pain symptoms. Methods 72 patients were randomly divided into duloxetine group （ n = 36 ） and fluoxetine group （ n = 36 ） for 8 weeks treatment. Hamilton rating scale for depression （ HAMD ）, Medical outcomes study pain measurement （ MOSPM ） and treatment emergent symtom scale （TESS）were used to evaluate the efficacy and side effects. Results The total sores of HAMD and MOSPM in both group after 8 weeks treatment were significantly lower than those in baseline（P 〈 0.01 ）, and the total and somatic symptom sores of MOSPM in duloxetine group was significantly lower than that of fluoxetine group after 8 weeks treatment （P 〈 0.05 ）. There were no significant difference in side effect between these two groups （P 〉 0.05 ）. Conclu- sion Both duloxetine and fluoxetine were effective in the treatment of depression with pain symptoms, while, duloxetine is more effective.
出处
《临床合理用药杂志》
2015年第26期8-9,共2页
Chinese Journal of Clinical Rational Drug Use
