α-干扰素超声雾化吸入法治疗小儿病毒性肺炎的临床观察

Effect of alpha interferon ultrasonic atomization inhalation In the treatment of infant severe pneumonia

目的观察α-干扰素超声雾化吸入法治疗小儿病毒性肺炎的临床疗效。方法选取2014年1月-2015年1月儿科门诊确诊为病毒性肺炎的患儿114例,随机分为观察组和对照组各57例。2组均给予支持、吸氧、对症治疗等。对照组予利巴韦林治疗,观察组予α-干扰素超声雾化吸入,5d为1个疗程。比较2组症状体征改善、住院时间及临床疗效。结果治疗组较对照组退热、咳嗽消失及肺啰音消失时间均缩短,住院时间亦短于对照组(P<0.05)。治疗组总有效率为82.5%显著高于对照组的63.2%,差异均有统计学意义(P<0.05)。观察组患儿雾化吸入过程中出现刺激性咳嗽2例,经处理,给予吸氧后症状消失;对照组无不良反应出现,2组患儿不良反应发生差异比较无统计学意义(P>0.05)。结论α-干扰素超声雾化吸入治疗小儿病毒性肺炎可显著改善患儿症状、体征及缩短住院时间,治愈率、安全性高,值得临床推广应用。

Objective To observe the clinical effect of alpha interferon ultrasonic atomization inhalation in the treat- ment of infant severe pneumonia. Methods 114 cases of viral pneumonia were randomly divided into observation group and control group with 57 cases in each group. 2 groups were given support, oxygen, symptomatic treatment, etc. The control group was treated with ribavirin ,The observation group was treated with interferon alpha interferon, and 5 days as a treatment course. To compare the clinical effect of the 2 groups. Results Symptom improvement time and hospitalization time in the treatment group were shorter than those in the control group, the difference was statistically significant （P 〈 0.05 ）. The total effective rate of the treatment group was 63.2%, significantly higher than that of the control group, the difference was statistically signifi- cant （P 〈 0.05 ） between the 2 groups. In the observation group, there were 2 cases of irritating cough, the symptoms disap- pea.red after oxygen inhalation, and no adverse reaction occurred in the control group, the difference was not statistically signifi- cant （ P 〉 0.05 ）. Conclusion Interferon alpha interferon in the treatment of viral pneumonia in children is safe and effective, can significantly improve the symptoms, signs and shorten the length of hospital stay, it is worthy of clinical application.