骨膜蛋白在支气管哮喘中的研究进展被引量：8

New Research Development of Periostion in Bronchial Asthma

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摘要骨膜蛋白,一种细胞外基质蛋白,属于成束蛋白家族,已经被报道在组织器官发育或修复的重构过程中起重要作用,慢性呼吸道炎症和气道重构是支气管哮喘的显著特征。研究发现,骨膜蛋白是白细胞介素(IL)4和IL-13的下游蛋白,IL-4和IL-13是Th2型免疫反应的特征细胞因子,骨膜蛋白是支气管哮喘的上皮下纤维化的组成部分,在过敏性哮喘的激活和维持阶段起重要作用。 Periostin, an extraeellular matrix protein belonging to the fasciclin family,has been reported to play a critical role in the process of remodeling during tissue and organ development or repair. Chronic airway inflammation and airway remodeling is the typical feature of bronchial asthma. Studies found that periostin is a downstream molecule of interleukin IL-4 and IL-13, signature cytokines of Th2 immune responses, a compo- nent of subepithelial fibrosis in bronchial asthma,playing a critical role in the activation and maintenance of allergic asthma.

作者石惠玲芦爱萍

机构地区广东医学院研究生学院深圳市第五人民医院儿科

出处《医学综述》 2015年第17期3105-3107,共3页 Medical Recapitulate

关键词支气管哮喘骨膜蛋白 Th2型免疫反应白细胞介素13 白细胞介素4 Brochial asthma Periostin Th2 immune responses Interleukin-13 Interleukin-4

分类号 R725.6 [医药卫生—儿科]

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