摘要
自噬是将细胞内受损、变性或衰老的蛋白质以及细胞器运输到溶酶体进行消化降解的细胞自我消化过程。自噬普遍存在于机体细胞中,往往在营养缺乏、低氧等特定环境以及细胞内应激(损伤的细胞器、细胞内突变的蛋白、微生物入侵等)状态下发生。近年来研究发现,自噬在许多肝脏疾病的发生、发展中起重要作用,该文就相关研究进展予以综述。
Autophagy is a self-digestive process by which the damaged,denatured or aging cellular proteins and organclles are transmitted and degraded in lysosomes. Autophagy widely exists in the body,especially under the circumstance like nutrition deprivation and hypoxemia and stress situation（ damaged cell organelle ;intracellular mutant protein, microbial invasion etc）. Increasing evidences have shown the remarkable role of auto- phagy in the occurrence and development in liver diseases, and here is to make a review of the research pro- gress
出处
《医学综述》
2015年第17期3116-3119,共4页
Medical Recapitulate
关键词
自噬
肝脏
肿瘤
自噬抑制剂
Autophagy
Liver
Neoplasm
Autophagic inhibitor
