血凝检测在肺癌患者中的应用

Application of coagulation function test in patients with lung carcinoma

目的探讨凝血功能检测在肺癌患者中的作用。方法利用STAGOSTA自动血凝分析仪对86例肺癌患者治疗前后和100例对照组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)、抗凝血酶Ⅲ(AT-Ⅲ)、纤维蛋白(原)降解产物(FDP)、D-二聚体(dimeride)进行检测。结果与对照组比较,肺癌组治疗前的Fib、FDP、D-二聚体均明显增加,具有统计学意义(P<0.05),而AT-Ⅲ明显减少,具有统计学意义(P<0.05)。肺癌组治疗后的Fib和FDP明显增加,具有统计学意义(P<0.05),而AT-Ⅲ明显减少,具有统计学意义(P<0.05),但D-二聚体增加无统计学意义(P>0.05)。与治疗前比较,治疗后的Fib、FDP、D-二聚体均明显减少,具有统计学意义(P<0.05),而AT-Ⅲ明显增加,具有统计学意义(P<0.05)。PT、APTT、TT在对照组及肺癌组治疗前后都不具有统计学意义(P>0.05)。结论凝血功能检测对肺癌患者治疗前后及预防血栓和/或癌栓形成具有重要的意义。

Objective To investigate the role of coagulation function test in patients with lung carcinoma. Methods A total of86 lung carcinoma and 100 healthy controls were enrolled. The prothrombin time,activated partial thromboplastin time,thrombin time,fibrinogen,antithrombin Ⅲ,fibrinogen degradation product and dimeride were detected with STAGO STA automatic coagulometer. Results The fibrinogen,fibrinogen degradation product,and dimeride were significantly higher among the lung carcinoma compared with healthy controls（P 0.05）,but the antithrombin Ⅲ were significantly lower among the lung carcinoma compared with healthy controls（P〈0.05）,The prothrombin time,activated partial thromboplastin time,thrombin time were no significantly between the lung carcinoma and healthy controls（P〉0.05）. Conclusion Coagulation function test may play an important role in prognosticating if the lung carcinoma would develp to and/or embolism,and could also monitor the progression and therapy.