期刊文献+

咪喹莫特乳膏联合普萘洛尔治疗婴幼儿颜面部血管瘤的观察 被引量:5

下载PDF
导出
摘要 目的观察咪喹莫特乳膏联合普萘洛尔治疗颜面部血管瘤的疗效和安全性。方法将104例颜面部婴幼儿型血管瘤患儿随机分成3组:联合组37例,予瘤体局部外用5%咪喹莫特乳膏,并口服普萘洛尔2mg/(kg·d);咪喹莫特组33例,予瘤体局部外用5%咪喹莫特乳膏;普萘洛尔组34例,口服普萘洛尔2mg/(kg·d)。定期随访,记录瘤体大小和颜色变化,总疗程均为6个月。结果联合组有效率为92%,咪喹莫特组有效率为67%,普萘洛尔组有效率为71%。联合组疗效高于咪喹莫特组和普萘洛尔组,差异均有统计学意义(P<0.05),各组副作用轻微且均较少见。结论咪喹莫特乳膏联合普萘洛尔治疗颜面部血管瘤效果明显且较为安全,不良反应轻微。
出处 《江西医药》 CAS 2015年第8期828-829,共2页 Jiangxi Medical Journal
  • 相关文献

参考文献11

  • 1Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children :a classification based on endothelial char- acteristics[J]. Plast Reconstr Surg, 1982,69(3) :412-422.
  • 2Greenberger S,Bischoff J. Infantile hemangioma-mechanism (s) of drug action on a vascular tumor [J]. Cold Spring Harb Perspect Med, 2011,1 (1) : a6460.
  • 3Aehauer BM,Chang CJ,Vander KV. Management of hemangioma of infancy :review of 245 patients [J]. Plast Reconstr Surg, 1997,99 (5) : 1301-1308.
  • 4Sehlosser KA. Infantile hemangioma:how to treat this benign neo- plasm of childhood[J]. JAAPA, 2009,22(5) :46-49.
  • 5Sauder DN. Immunomodulatory and pharmacologic properties of im- iquimod[J]. J Am Acad Dermatol, 2000,43(1 Pt 2) : S6-S 11.
  • 6Senchak A J, Dann M,Cable B,et al. Successful treatment of cuta- neous hemangioma of infancy with topical imiquimod 5% : a report of 3 cases[J]. Ear Nose Throat J,2010,89(3) : E21-E25.
  • 7顾永,周南,施和建.局部外用5%咪喹莫特乳膏治疗婴儿血管瘤临床观察[J].中华皮肤科杂志,2012,45(12):909-910. 被引量:3
  • 8陈富祺,李雪莲,郭祖安.5%咪喹莫特乳膏联合普萘洛尔治疗婴幼儿血管瘤42例疗效观察[J].中国中西医结合皮肤性病学杂志,2014,13(2):93-95. 被引量:3
  • 9Leaute-Labreze C ,Dumas DLRE ,Hubiche T,et al. Propranolol for severe hemangiomas of infancy [J]. N Engl J Med,2008,358(24): 2649-2651.
  • 10杨舟,李丽,徐子刚,孙玉娟,张立新,张霞1,褚岩,燕丽,刘盈,肖媛媛,向欣,王忱,马琳.普萘洛尔治疗婴儿血管瘤的临床疗效及安全性[J].中华皮肤科杂志,2012,45(7):466-469. 被引量:36

二级参考文献22

  • 1Waner M,Suen JY.Management of congenital vascular lesions of the head and neck[J].Oncology,1995,9:989-994.
  • 2Achauer BM,Chang CJ,Vander Kam VM.Management of hemangioma of infancy:review of 245 patients[J].Plast Reconstr Surg,1997,99:1 301-1 308.
  • 3Léauté-Labrèze C,Dumas de la Roque E,Hubiche T,et al.Propranolol for severe hemangiomas of infancy[J].N Engl J Med,2008,358:2649-2651.
  • 4Léanté-Larèze C,Dumas de la Roque E,Huhiche T. Propranolol for severe hemangiomas of infancy[J].New England Journal of Medicine,2008,(24):2649-2651.
  • 5Manunza F,Syed S,Laguda B. Propranolol for complicated infantile haemangiornas:a case series of 30 infants[J].British Journal of Dermatology,2010,(02):466-468.doi:10.1111/j.1365-2133.2009.09597.x.
  • 6Sans V,de la Roque ED,Berge J. Propranolol for severe infantile hemangiomas:follow-up report[J].Pediatrics,2009,(03):e423-e331.doi:10.1542/peds.2008-3458.
  • 7De Graaf M,Breur JM,Raphaěl MF. Adverse effects of propranolol when used in the treatment of hemangiomas:a case series of 28 infants[J].Journal of the American Academy of Dermatology,2011,(02):320-327.
  • 8Achauer BM,Chang CJ,Vander Kam VM. Management of hemangioma of infancy:review of 245 patients[J].Plastic and Reconstructive Surgery,1997,(05):1301-1308.doi:10.1016/j.jtbi.2005.03.006.
  • 9Lawley LP,Siegfried E,Todd JL. Propranolol treatment for hemangioma of infancy:risks and recommendations[J].Pediatric Dermatology,2009,(05):610-614.doi:10.1111/j.1525-1470.2009.00975.x.
  • 10Haider KM,Plager DA,Neely DE. Outpatient treatment of perioeular infantile hemangiomas with oral propranolol[J].Journal of American Association for Pediatric Ophthalmology and Strabismus,2010,(03):251-256.doi:10.1016/j.jaapos.2010.05.002.

共引文献39

同被引文献86

引证文献5

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部