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上皮间质转化与肿瘤转移的研究进展 被引量:5

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摘要 上皮细胞间质转化(epithelial-mesenchymal transition,EMT)是指具有极性的上皮细胞通过特定程序转化为具有活动能力的间质细胞的过程,其公认的标志有上皮细胞标志物E钙黏蛋白(E-cadherin)、角蛋白等表达下调,间质细胞标志物波形蛋白(vimentin)表达上调,进而细胞获得迁移和侵袭能力。EMT在多种生理病理过程中发挥重要作用,
出处 《中国耳鼻咽喉颅底外科杂志》 CAS 2015年第4期346-350,共5页 Chinese Journal of Otorhinolaryngology-skull Base Surgery
基金 国家自然科学基金资助项目(81272974 81472696)
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