三种凝血功能指标改变与肝硬化相关性讨论

Correlation Discussion into Three Types of Blood Coagulation Function Index Changes and cirrhosis

目的:研究三项凝血功能指标改变与肝硬化及分级程度是否具有相关性。方法:观察100例不同Child pugh分级肝硬化患者凝血功能改变,以及55例正常健康体检人员为对照,研究凝血指标与肝硬化Child pugh评分相关性。结果:肝硬化组及对照组凝血酶原(PT)活化部分凝血活酶时间(APTT)纤维蛋白原(FIB)比较差异有统计学意义(P<0.05);肝硬化组不同Child pugh分级的PT比较差异有统计学意义(P<0.05),C级的APTT、FIB均高于A级及B级;PT与Child pugh评分呈正相关。结论:PT、APTT、FIB三项凝血指标的改变能够反映出肝硬化病程改变,两者之间有相关性。

Objective： To study the correlation of changes of three types of blood coagulation function index changes and cirrhosis. Methods： to observe changes of blood coagulation function of 100 cases of cirrhosis cases with different Child pugh level, 55heahhy subjects undergoing health check were chosen as the control group, in order to study the correlation of blood coagulation and Child pugh score of cirrhosis. Results： There are significant difference between cirrhosis group and control group in terms of PT, APTT and FIB ;and PT of Child pugh level of cirrhosis group has statistical difference,FIB of level C APTT is higher than that of level A and B; positive correlation was found between PT and Child Pugh score. Conclusion： There is correlation between the two factors. Changes of PT,APTT,FIB can indicate the progress of cirrhosis