过敏性鼻炎-哮喘综合征7种治疗方法的成本-效果分析

The Cost-Effectiveness Analysis of Seven Kinds of Treatment of Allergic Rhinitis-Asthma Syndrome

目的从药物经济学的角度探讨过敏性鼻炎-哮喘综合征(CARAS)治疗方法的成本-效果,从而合理选择治疗药物。方法将280例CARAS患者根据药物应用的不同随机分成糖皮质激素组(A组)、抗组胺组(B组)、白三烯受体拮抗剂(C组)、抗-Ig E单克隆抗体组(D组)、转移因子组(E组)、糖皮质激素+转移因子组(F组)、糖皮质激素+抗-Ig E单克隆抗体组(G组),分别应用相应的药物治疗。结果 D,E,F组与G组的有效率均高于A,B,C组(P<0.05);C,D,F组与G组的成本明显高于A,B,E组(P<0.05);A,B组与E组的C/E值明显少于其他组(P<0.05)。结论糖皮质激素法、抗组胺法与转移因子法是治疗CARAS的最佳治疗方法。

Objective To investigate the cost effective theraPy for allergic rhinitis- asthma syndrome,from the Point of view of Pharma-ceutical economics,to choose the reasonable treatment of drug. Methods 280 cases of allergic rhinitis-astlma syndrome Patients were equally divided into glucocorticoid grouP（A）,the anti histamine grouP（B）,leukotriene recePtor antagonist grouP（C）,anti-IgE monoclonal antibody grouP（D）,transfer factor grouP（E）,glucocorticoid add transfer factor grouP （F） and glucocorticoid add anti-IgE monoclonal antibody grouP（G） dePending on the drug aPPlication resPectively,each with aPProPriate medication. Results The effective rates of grouP D,E,F and G were higher than grouP A,B,C（ P 〈 0. 05）;the cost of grouP C,D,F and G were significantly higher than grouP A,B,E（ P 〈 0. 05）,the C/ E values of grouP A,B and E were significantly less than the other grouPs（ P 〈 0. 05）. Conclusion The method of glucocorticoid law,the anti histamine and the transfer factor are the best treatment for treating allergic rhinitis-asthma syndrome.