酚磺乙胺预防子宫切除术后出血120例及最佳下床活动时间观察

Curative Effect of Etamsylate Injection in Reducing Bleeding After Hysterectomy and Best Bed Activity Time in 120 Cases

目的：探讨酚磺乙胺注射液用于子宫切除术减少术后出血的疗效及最佳下床活动时间。方法选取医院收治的子宫肌瘤患者120例，均行腹腔镜辅助阴式子宫切除术（LAVH）治疗，术前给予酚磺乙胺注射液（术前15～30 min静脉滴注0.25～0.5 g）。并根据下床活动时间的不同，随机分为A组、B组、C组，各40例。A组术后24 h内下床活动，B组术后25～48 h下床活动，C组术后48～72 h下床活动。结果120例患者手术用时（102.2±17.5）min；术中出血量为（102.63±11.54）mL，术后2 h出血量为（55.32±10.32）mL，术后2～24 h出血量为（67.56±18.67）mL，术后24 h总出血量（109.36±19.84）mL。所有患者术中血压平稳，无不良事件发生；术后均无血管栓塞发生。与B组及C组相比，A组术后肛门排气时间提前（ P＜0.05），发热天数、住院天数均缩短（ P＜0.05）。3组术后阴道断端出血情况与疼痛程度比较无显著性差异（ P＞0.05）。结论对于行LAVH的子宫肌瘤患者，术前应用酚磺乙胺药物，可有效缩短手术时间，控制术中、术后出血量，减少不良事件发生率。子宫切除术后24 h内下床活动可有效促进肛门排气，缩短术后发热及住院天数。

Objective To investigate the curative effect of etamsylate injection in reducing bleeding after hysterectomy and PostoPerative best bed activity time. Methods 120 Patients with uterine fibroids were selected,all Patients were Performed laParoscoPic assisted vaginal hysterectomy （ LAVH ） ,and given etamsylate injection PreoPerative （ PreoPerative 15-30 minutes by intravenous driP or intramuscular injection of 0. 25-0. 5 g ） . The Patients were randomly divided into grouP A, grouP B and grouP C according to the different bed activity time,40 cases in each grouP. GrouP A made off-bed activity within 24 h after oPeration,grouP B 25-48 h and grouP C,48-72 h. Results The oPeration time of the 120 Patient was （ 102. 2 ± 17. 5 ） min; intraoPeratie blood loss was （ 102. 63 ± 11. 54 ） mL,（ 55. 32 ± 10. 32 ） mL after 2 h,（ 67. 56 ± 18. 67 ） mL after 2-24 h,the total blood loss after 24 h was （ 109. 36 ± 19. 84 ） mL. The intraoPerative blood Pressure of all Patient was stable,with no adverse events; no PostoPerative vascular embolization occured. ComPared with grouP B,and grouP C,PostoPerative anal exhaust time was advanced in grouP A （ P 〈 0. 05 ） ,the fever days,hosPitalization days were short-ened in grouP A （ P 〈 0. 05 ） ,the difference is significant. The vaginal bleeding and Pain of incision had no difference in the 3 grouPs （ P 〉 0. 05 ） . Conclusions For Patients with uterine fibroids LAVH,the PreoPerative use of etamsylat drugs can short oPeration time, control oPeratine and PostoPerative vaginal haemorrhage amount,reduce the incidence of adverse reactions, the best PostoPerative bed time is within 24 h,which can Promote the anus exhaust shorten fever days and hosPitalization days.