儿童过敏性紫癜的危险因素分析

Risk Factors Analysis of Children Henoch-Schonlein Purpura

目的 分析儿童过敏性紫癜的危险因素,为寻找致病原因提供针对性的治疗措施提供理论依据。方法通过对广州医科大学附属第二医院儿科2004~2013年住院诊断过敏性紫癜306例患儿进行回顾性分析,比较其临床特征,对肺炎支原体、幽门螺旋杆菌、链球菌等病原体检测结果进行比较分析,同时对螨虫、食物等过敏原检测结果进行分析,从而获知其致病的主要危险因素。结果 儿童过敏性紫癜临床表现分型以皮肤型为主,约占89.2%。致病微生物中,肺炎支原体感染阳性比例为34.9%,幽门螺旋杆菌2.6%,链球菌4.9%。血过敏原测定螨虫过敏原阳性率34.8%,食物等过敏24.7%。结论 感染仍为过敏性紫癜第一位的致病因素,肺炎支原体感染是主要的致病微生物之一,螨虫为主要的过敏因素。过敏性紫癜的治疗应针对病原菌及过敏因素制定方案、方可奏效并防止复发。

Objective To analyze the risk factors of children Henoch- Schonlein purpura （HSP） and provide theoretical basis for targeted therapy. Methods All the patients were hospitalized from pediatrics department of the Second Affiliated Hospital of Guangzhou Medical University from 2004 to 2013. All of 306 patients diagnosed as HSP were retrospectively analyzed to compare the clinical characteristics and the pathogen test results of mycoplasma pneumoniae, helicobacter pylori, and streptococcus. The allergen test results of mites and food are also compared and analyzed. Results The main type of children HSP is skin type accounted for about 89.2 %. The mycoplasma pneumoniae infection positive rate was 34.9 % , helieobaeter pylori 2.6 %, streptococcus 4.9%. The mite allergy allergen test positive rate was 34.8% ,food allergies 24.7%. Conclusion The infection is still the first pathogenic factors of Henoch Schonlein purpura. Pneumonia mycoplasma infection is one of the main pathogenic microorganisms, while mite is one of the main allergy factors. To increase curative effect of HSP, shorten course and reduce the recurrence, specific diagnosis and corresponding treatment should be given according to the diagnosis of pathogenic bacteria and allergen.