女性子宫颈感染人乳头瘤病毒的基因分布、感染状况及其危险因素分析

Analysis on gene distribution,infection status and risk factors of human papillomavirus in women cervical infection

目的探讨女性子宫颈感染人乳头瘤病毒（HPV）的基因分布、感染状况及其危险因素。方法选取2013年1月至2014年9月该院妇产科收治的患者350例。结果 350例患者中,HPV阳性44例,阳性率12.57%。液基细胞学检测（LCT）阳性患者的感染率显著高于正常者（P〈0.05）,不同程度宫颈病变的HPV52型检出率之间差异有统计学意义（P〈0.05）。HPV感染和宫颈细胞学分级具有相关性（OR=2.219,95%CI为1.665～2.958）;31～35岁、41～45岁患者的HPV感染率显著高于小于25岁及大于50岁患者（P〈0.05）;25～27岁生育人群的HPV感染率显著高于28岁以后生育人群（P〈0.05）;不同结婚年龄、初潮年龄、初产年龄、妊娠次数、妇科疾病史、肿瘤家族史、妇科检查情况患者的HPV感染之间的差异均无统计学意义（P〉0.05）,不同产次、是否使用避孕套患者的HPV感染率之间差异均有统计学意义（P〈0.05）。结论女性子宫颈感染HPV的基因亚型主要为HPV39、HPV16、HPV58,主要危险因素为产次、是否使用避孕套。临床应给予女性子宫颈感染HPV的基因分布、感染状况及危险因素以充分的重视并对其进行进一步全面深入的分析。

Objective To analyze the gene distribution ,infection status and risk factors of human papillomavir‐us （HPV） in women cervical infection .Methods The clinical data in 350 cases of HPV cervical infection treated in the obstetrics and gynecology department of this hospital from January 2013 to September 2014 were statistically an‐alyzed .Results Among 350 cases ,HPV‐positive was in 44 cases with the positive rate of 12 .57% .The infection rate in the liquid based cytology（LCT）‐positive patients was significantly higher than that in normal individuals （P〈0 .05） ,the HPV52 detection rate had statistical differences among different degrees of cervical lesions （P〈0 .05） . The HPV infection and cervical cytology classification had the correlation（OR=2 .219 ,95% CI of 1 .665 -2 .958）;the HPV infection rates in the 31-35 years old patients and the 41-45 years old patients were significantly higher than that in the 〈25 years old patients and 〉50 years old patients （P〈0 .05）;the HPV infection rate in the 25-27 year old childbearing crowd was significantly higher than that after the 〉28‐year‐old childbearing crowd（P〈0 .05）;the HPV infection rate had no statistical differences among different marriage age ,menarche age ,primiparous age , pregnancy number ,history of gynecological diseases ,family history of tumor and gynecological examination situation （P〉0 .05） ,the HPV infection rate had statistical differences among different parities and whether using condom （P〈0 .05） .Conclusion Female cervical HPV infection subtypes are mainly HPV39 ,HPV16 and HPV58 ,the main risk factors are parity and whether useing condom .The clinic should give the sufficient attention to the gene distribution , infectious status and risk factors in female cervical HPV infection and the further comprehensive in‐depth analysis should be conducted .