盐酸羟考酮联合音乐疗法在中重度癌痛患者中的应用

Application of oxycodone hydrochloride combined with music therapy in patients with moderate to severe cancer pain

目的探讨盐酸羟考酮联合音乐疗法对改善癌症患者疼痛的疗效。方法将该院肿瘤科收治的中重度癌痛患者纳入研究范围,按入院先后顺序随机分为两组,分别给予不同的治疗方法,A组给予盐酸羟考酮作为对照组,B组给予盐酸羟考酮联合音乐疗法作为试验组,对其临床疗效、用药剂量、功能状态评分、生活质量评分、药物不良反应进行统计学分析。结果两组患者疼痛程度均较治疗前显著减轻,两组比较差异有统计学意义(P<0.05);A组用药剂量大于B组,两组比较差异有统计学意义(P<0.05);两组患者治疗后功能状态评分、生活质量评分改善率比较,差异有统计学意义(P<0.05);两组不良反应便秘、头晕、恶心、呕吐、嗜睡等比较,差异有统计学意义(P<0.05),其他不良反应尿潴留发生率两组比较差异无统计学意义(P>0.05)。结论在临床治疗中,中重度癌痛患者中应用盐酸羟考酮配合音乐疗法对缓解患者癌痛方面,具有镇痛效果确切、操作方便,不良反应小、安全性高,可有效改善患者生活质量,是目前治疗中重度癌痛较佳的选择,为临床肿瘤镇痛治疗提供了一种新的选择方式,值得在临床中推广应用。

Objective To investigate the effect of oxycodone hydrochloride combined the music therapy for im‐proving pain in the patients with cancer .Methods The patients with moderate to severe cancer pain admitted to our hospital were included in the study and randomly divided into two groups according to the order of admission .The two groups were respectively given different treatment methods .The group A was given oxycodone hydrochloride as the control group and the group B received the therapy of oxycodone hydrochloride combined with the music therapy as the experimental group .The clinical efficacy ,dosage ,KPS score ,QOL score and adverse drug reactions were ana‐lyzed statistically .Results The pain degree after treatment in the two groups was significantly reduced compared with before treatment ,the difference was statistically significant（P〈0 .05）;the dose in the group A was greater than that in the group B ,the difference was statistically significant（P〈 0 .05）;the improvement rate of KPS and QOL scores after treatment had statistically significant differences between the two groups （P〈0 .05）;the adverse reac‐tions of constipation ,dizziness ,nausea ,vomiting and drowsiness had statistically significant difference between the two groups（P〈0 .05） ,in the other adverse reactions ,the occurrence rate of urinary retention had no statistically sig‐nificant difference between the two groups（P〉0 .05） .Conclusion In clinical treatment of the patients with moderate to severe cancer pain ,oxycodone hydrochloride combined with the music therapy has definite analgesic effect ,easy op‐eration ,few adverse reactions and high security in alleviating cancer pain ,can effectively improve the live quality of patients ,provides a new elective mode for the clinical tumor analgesia and deserves to be clinically promoted and ap‐plied .