阿尔茨海默病的静息态功能磁共振、弥散张量成像及脑灌注研究进展（英文）

Resting state functional MRI,DTI and PWI in the Alzheimer's disease

阿尔茨海默病(Alzheimer’s disease,AD)以认知和记忆能力下降为主要特征,轻度认知功能障碍是AD的早期阶段,AD的病理生理机制目前尚不清楚,本文综述了AD有关的神经影像学研究,通过应用磁共振成像新技术包括静息态脑功能成像、弥散张量成像、脑灌注成像,有助于我们从功能、结构和灌注的角度更深入理解AD的病理生理机制。本文对此做简要综述。

Alzheimer＇ s disease（AD） is characterized as cognitive and memory decline. Mild cognitive impairment（MCI） is the early stage of AD. The pathophysiology of AD is not very clear. In the present article, we reviewed the previous neuroimaging study of AD. By using the new MRI techniques including resting state functional MRI （ fMRI）, diffusion tensor imaging （DTI） and perfusion weighted imaging（ PWI）, we can acquire deep understanding of the pathophysiology of AD from the prospect of function, structure and perfusion.