摘要
目的:建立了能够同时测定丹参注射剂中6种无机阴离子(氟离子、甲酸根、氯离子、亚硝酸根、溴离子和硝酸根)含量的离子色谱方法。方法:采用IC-2100离子色谱,Ion Pac AS11-HC阴离子色谱柱(4 mm×250 mm),KOH梯度淋洗,电导检测器检测6种无机阴离子含量。结果:6种无机阴离子基本达到基线分离,线性关系良好,相关系数分别在0.999 5-0.999 9,平均回收率分别在90.1%-106.5%。结论:所建立的方法快速、准确、简便、实用,可用于丹参注射剂中6种无机阴离子的含量测定和质量控制。
Objective: An ion chromatography method for simultaneous determination of six inorganic anions( fluoride,formic,chloride,nitrite,bromide and nitrate) in Danshen injection was established. Method:Six inorganic anions were determined by anion exchange column Ion Pac AS11-HC( 4 mm × 250 mm),eluted by gradient hydroxide potassium. Result: Good resolution can be achieved among the above mentioned six inorganic anions. Their linear correlations over the investigated concentration were in the range of 0. 999 5-0. 999 9,while the average recoveries ranged from 90. 1% to 106. 5%,respectively. Conclusion: The ion chromatography method is fast,accurate,simple,reliable and applicable for the determination and quality control of inorganic anions in Danshen injection.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第17期24-27,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重大科学仪器设备开发专项(2012YQ14000806)
国家质检总局科技计划专项(2014Ik084)
质检公益性行业科研专项(201410088-02)
辽宁省科学技术厅自然科学基金项目(201202252)
关键词
离子色谱
丹参注射剂
无机阴离子
超声波提取法
ion chromatography
Danshen injection
inorganic anion
ultrasonic extraction