银屑胶囊联合吡硫翁锌气雾剂治疗寻常型银屑病65例

Yinxie Capsule Combined with Pyrithione Zinc Aerosol in Treating 65 Cases of Psoriasis Vulgaris

目的:观察银屑胶囊联合吡硫翁锌气雾剂治疗寻常型银屑病的临床疗效及对患者血液流变学和血清肿瘤坏死因子-α(TNF-α),白细胞介素-8(IL-8),基质金属蛋白酶-2(MMP-2),基质金属蛋白酶-9(MMP-9)水平的影响。方法:采用随机按数字表法将130例寻常型银屑病患者分为对照组和观察组各65例。对照组外用吡硫翁锌气雾剂靶皮损喷洒治疗,3次/d;观察组在对照组治疗的基础上口服银屑胶囊,4粒/次,3次/d。两组疗程均为8周。进行治疗前后的皮损面积和严重程度指数(PASI),瘙痒程度视觉模拟(VAS)及皮肤病生活质量指数(DLQI)评分;检测治疗前后血液流变学及血清TNF-α,IL-8,MMP-2,MMP-9水平。结果:观察组愈显率为89.23%,对照组愈显率为73.85%,观察组优于对照组(P<0.05);治疗后观察组PASI评分,瘙痒VAS和DLQI均低于对照组(P<0.01);治疗后观察组血液流变学各项指标改善均优于对照组(P<0.01);治疗后观察组TNF-α,IL-8,MMP-2,MMP-9水平均显著低于对照组(P<0.01)。结论:银屑胶囊联合吡硫翁锌气雾剂治疗寻常型银屑病临床疗效优于单纯使用吡硫翁锌气雾剂,其作用机制可能与其降低血液黏度和血清TNF-α,IL-8,MMP-2,MMP-9水平有关。

Objective： To observe the therapeutic efficacy of Yinxie capsule combined with Pyrithione Zinc aerosol in the treatment of psoriasis vulgaris and its effect on hemorheology and serum tumor necrosis factor-α（ TNF-α）,interleukin-8（ IL-8）,matrix metalloproteinases-2（ MMP-2）,matrix metalloproteinases-9（ MMP-9）.Method： Altogether 130 patients with psoriasis vulgaris were divided into the control group and the observation group by random number table,with 65 patients in each group. The control group was treated by spraying Pyrithione Zinc aerosol,three times / d. In addition to the therapy of the control group,the observation group also took Yinxie capsule,4 capsules,tid. The course of treatment were 8 weeks for two groups. psoriasis area and severity index（ PASI）,visualanaloguescale（ VAS） and dermatology life qualityindex（ DLQI） were scored in both groups before and after the treatment. The hemorheology and serum TNF-α,IL-8,MMP-2,MMP-9 were detected before and after the treatment. Result： The markedly effective rate of the observation group was 89. 23%,which was superior to the control group（ 73. 85%,P〈0. 05）. After the treatment,the scores of PASI,VAS and DLQI in the observation group were obviously lower than that of the control group（ P〈0. 05）. The hemorheological indexes of the observation group were superior to that of the control group after the treatment（ P〈0. 05）. The serum TNF-α,IL-8,MMP-2 and MMP-9 in the observation group were lower than that of the control group after the treatment（ P〈0. 05）. Conclusion： Yinxie capsule combined with Pyrithione Zinc aerosol in the treatment of psoriasis vulgaris is more effective than the simple use of Pyrithione Zinc aerosol. Its mechanism may be correlated with the reduction in plasma viscosity and serum TNF-α,IL-8,MMP-2 and MMP-9.