尿激酶联合抗结核药胸腔内注入对结核性包裹性胸腔积液治疗及其预后的影响

Tuberculosis Medicne Chest Cavrity Iniection of Tubetculous wrap Effects of Pleural Effasion Ttreatment

目的观察尿激酶联合抗结核药胸腔内注入对结核性包裹性胸腔积液预后的疗效影响。方法将72例结核性包裹性胸腔积液病人,在常规规范抗痨的基础上随机分为治疗及对照组,每组各36例,对照组行常规胸腔彩超引导胸穿,治疗组行胸穿外,加胸腔内注入尿激酶、异烟肼、利福平。比较两组的胸水消失时间,住院治疗时间,治疗后胸膜增厚及粘连程度,肺功能改善情况。结果胸腔内注入尿激酶联合抗结核药物治疗结核性包裹性积液。结论尿激酶联合抗结核药胸腔内注入对胸水消失时间、明显减轻胸膜肥厚,对胸膜粘连及其改善肺功能有明显的疗效。

Objective To investigate the effect of intrapleural injection of urokinase and anti - TB on curing tuberculous encap-sulated pleural effusion. Methods 72patients suffering from tuberculousencapsulated pleural effusion underwent regular anti - TB treatment and were randomly divided into Treatment and Control group,each group 36 cases. The control group underwent routine chest ultrasound guided thoracentesis,and the Treatment group plus intrapleural injection of urokinase,isoniazid and rifampicin be-sides routine thoracentesis. To measure the pleural effusion disappear time,hospitalization time,and pleural thickening and adhesion, lung function of the two groups before and after treatment. Results The method that intrapleural injection ofurokinase combined anti -TB to cure tuberculous encapsulated pleural effusion has curative effect on shortening pleural effusion disappear time. Conclusion re-ducing pleural thickening and improving pleural adhesions and lung function.