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芝麻素通过PI3K/Akt信号通路抑制肥大细胞活化研究 被引量：1

Study of sesamin on inhibiting mast cell activation through PI3K/Akt signaling pathway
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摘要 [目的]观察芝麻素对肥大细胞活化的影响并探讨其可能作用机制.[方法]通过IgE介导体外实验观察芝麻素对IgE介导的肥大细胞组织胺的释放及对PI3K/Akt蛋白表达的影响.[结果]与模型对照组比较,芝麻素大、中剂量可明显抑制肥大细胞释放组织胺,且可有效抑制肥大细胞释放炎性细胞因子PI3K/Akt蛋白的表达(P<0.05).[结论]芝麻素抗过敏作用可能部分与抑制PI3K/Akt信号通路有关. OBJECTIVE To study the effect and its mechanism of sesamin for mast cell activation.METHODS The effects of sesamin for IgE-induced histamine release of mast cells and expression of PI3K/Akt were observed in vitro.RESULTS As compared with the model control group,high dose and moderate dose of sesamin inhibited significantly the histamine release of mast cells and the expression of PI3K/Akt（P〈0.05）.CONCLUSION Anti-allergic effects of sesamin might be related to inhibition of PI3K/Akt signaling pathway.
作者 李光昭 朴红梅 李良昌 秦向征 延光海
机构地区 延边大学医学院解剖学教研室 延边大学附属医院呼吸内科
出处 《延边大学医学学报》 CAS 2015年第1期8-10,共3页 Journal of Medical Science Yanbian University
基金 吉林省科技厅项目(20130101121JC) 吉林省教育厅项目(吉教科合字2014第21号)
关键词 肥大细胞 芝麻素 组胺 PI3K/AKT 大鼠 mast cell sesamin histmaine PI3K/Akt rats
分类号 R285 [医药卫生—中药学]
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参考文献8

  • 1洪海,金光日,金光玉,延光海.桑黄多糖对肥大细胞脱颗粒的机制[J].中国医院药学杂志,2011,31(18):1532-1534. 被引量：5
  • 2Monteiro EM, Chibli LA, Yamamoto CH, et al: An- tinociceptive and anti-inflammatory activities of the sesame oil and sesamin [J]. Nutrients, 2014, 6 (5) 1931-1944.
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二级参考文献7

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延边大学医学学报
2015年 第1期

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