结直肠癌与代谢综合征的相关性

Study on correlation between metabolic syndrome and colorectal cancer

[目的]探讨代谢综合征（MS）及其组分与结直肠癌的相关性.[方法]选择住院的结直肠癌患者144例作为病例组、社区健康体格检查者156例作为对照组进行病例对照研究.分析MS及其组分异常与结直肠癌的关系及影响肿瘤的危险因素.[结果]病例组血清三酰甘油（TG）、血糖（GLU）及体质量指数（BMI）水平均明显高于对照组（P〈0.01）,血清高密度脂蛋白胆固醇（HDL-C）水平明显低于对照组（P〈0.01）.MS、高TG、高GLU及肥胖者患结直肠癌的相对危险度分别为4.240（95%CI：1.935~9.288）,1.775（95%CI：1.034~3.048）,2.125（95%CI：1.215~3.716）和2.502（95%CI：1.460~4.288）.[结论]结直肠癌与MS及其组分密切相关,特别是与TG,HDL-C,BMI和GLU水平密切相关.

OBJECTIVETo study the correlation between items of metabolic syndrome（MS）and colorectal cancer.METHODS Case control study was performed in 144 patients with colorectal cancer as case group and in 154 healthy people with physical examination in community as control group,and it was analyzed that the relationship between colorectal cancer and items of metabolic syndrome and the risk factors of colorectal cancer.RESULTSThe contents of triglyceride（TG）,glucose（GLU）of serum and BMI were significantly higher in the case group than in the control group（P〈0.01）,and content of high-density lipoprotein cholesterol（HDL-C）was significantly lower in the case group than in the control group（P〈0.01）.Relative risks of MS,high TG,high GLU and obesity for suffering from colorectal cancer were 4.240（95%CI：1.935-9.288）,1.775（1.034-3.048）,2.125（1.215-3.716）and 2.052（1.460-4.288）.CONCLUSION Colorectal cancer is closely related to items of MS,especially the TG,HDL-C,GLU and BMI.