CGA,Survivin蛋白在胃黏膜不同病理状态下的表达及其意义

Expression and its significance of CGA and Survivin in different pathological state of gastric mucosa

[目的]观察CGA,Survivin蛋白在胃黏膜不同病理状态下的表达情况,探讨胃黏膜病理变化过程中的最佳外科癌前干预节点,并为胃癌生物靶向治疗寻找新的靶点.[方法]应用免疫组织化学方法检测CGA及Survivin蛋白在慢性浅表性胃炎、慢性萎缩性胃炎、胃黏膜不典型增生及胃癌组织中的表达,并进行相关性分析.[结果]胃黏膜不典型增生组CGA及Survivin蛋白表达明显高于慢性萎缩性胃炎组(P<0.05),胃癌组明显高于胃黏膜不典型增生组(P<0.05),且CGA表达与Surviviv表达呈正相关.[结论]胃黏膜不典型增生阶段是外科干预的最佳节点,Survivin有望成为胃癌生物靶向治疗的新的靶点.

OBJECTIVETo explore the best time of surgery intervene in the course of pathologic changes of gastric mucosa and search for new biotherapeutics target of gastric cancer by means of detecting the expression of CGA and survivin in gastric mucosa.METHODSExpressions of CGA and survivin in chronic superficial gastritis,chronic atrophic gastritis,dysplasia of gastric mucosa and gastric cancer were detected by immunohistochemistry,and its correlation analysis was performed.RESULTS The expression of CGA and survivin was significantly higher in group of gastric mucosa dysplasia than in group of chronic atrophic gastritis（P〈0.05）and in group of gastric cancer than in group of gastric mucosa dysplasia（P〈0.05）,and the expression of CGA had positive correlation with the expression of survivin.CONCLUSIONThe stage of gastric mucosa dysplasia is the best time of surgery intervene,and survivin is expected to be a new biotherapeutics target of gastric cancer.