中心动脉压与冠心病的相关性

Association of Central Aortic Pressure,Homocysteine and Coronary Heart Disease

目的对疑诊冠心病的原发性高血压患者行冠状动脉造影术,检测有创中心动脉压,探讨中心动脉压与冠心病的相关性。方法选择2013年7~12月在内蒙古自治区人民医院心内科住院治疗的疑诊冠心病的原发性高血压患者126例,其中男67例,女59例,年龄43~82岁,平均年龄（64.44±9.83）岁。根据冠脉造影结果分为冠心病组及非冠心病组,对冠心病组进行Gensini评分,冠脉造影术前测定同型半胱氨酸,冠脉造影术中记录中心动脉压,并采用SPSS 13.0统计软件分析所有数据。结果 （1）两组中心动脉收缩压比较差异有统计学意义（P〈0.01）,冠心病组中心动脉收缩压（151.47±20.55）mmHg高于非冠心病组（128.06±11.65）mmHg。（2）冠心病组中心动脉收缩压与冠状动脉Gensini积分的相关性分析显示两者呈正相关（r=0.319,P〈0.01）。结论 （1）冠心病组中心动脉收缩压较非冠心病组高,多变量Logistic回归分析提示中心动脉收缩压与冠心病密切相关,是冠心病的独立危险因素;（2）冠心病组中心动脉收缩压与冠状动脉Gensini积分呈正相关,对冠状动脉病变程度有一定的预测价值。

Objective In the present study,we detected the suspected coronary artery disease patients with essential hypertension using coronary angiography in order to detect invasive central blood pressure,arterial pressure center,and to explore relevance between invasive central blood pressure and arterial pressure noninvasively center.Methods We chose the suspected coronary artery disease patients with essential hypertension ranging from July 2013 to December 2013 in Inner Mongolia People＇s Hospital,whose number was 126 cases,including 67 males and 59 females,aged 43-82 years old.The average age is（64.44±9.83）years old.According to the results of coronary angiography we divided them into two groups,coronary heart disease group and non- coronary heart disease group,Gensini score of coronary heart disease group.we recorded the central arterial pressure.At last we analyze all data using statistical software SPSS13.0.Results（1）There were apparently significant differences between two central systolic blood pressure（P〈0.01）,coronary heart disease group central systolic blood pressure（151.47±20.559）mmHg〗were higher than non-coronary heart disease group（128.06±11.65）mmHg.（2）Central aortic systolic pressure and Gensini scores of coronary artery was positively correlated with each other（r=0.319,P〈0.01）.Conclusions（1）Coronary heart disease group central systolic blood pressure was higher than noncoronary heart disease group,suggesting that central arterial pressure was closely related to coronary heart disease.Central arterial pressure was independent risk factors for coronary heart disease;（2）Central aortic systolic pressure and Gensini scores of coronary artery was positively correlated with each other,had some predictive value to the extent of coronary heart disease.