宫颈癌上皮间质转化相关因子ZEB1与microRNA-200c的关系

Relationship between microRNA-200c and ZEB1 of epithelial mesenchymal transition factor in cervical cancer

目的：探讨宫颈癌上皮间质转化相关因子ZEB1与microRNA-200c水平及其意义。方法选取2013年7月～2015年1月于厦门大学附属第一医院普外科已确诊为宫颈癌的患者50例，取其肿瘤部位组织作为实验组，同期选取50例在本院行子宫肌瘤切除手术患者的子宫颈正常组织作为对照组，检测2组患者子宫组织的ZEB1与microRNA-200c水平。结果实验组ZEB1平均水平明显高于对照组（P＜0.05），在宫颈癌中是否淋巴转移及深肌层浸润组之间差异均有统计学意义（P＜0.05）；实验组microRNA-200c平均水平低于对照组（P＜0.05）；在宫颈癌中不同肿瘤病理分级组、是否淋巴转移及深肌层浸润组之间差异有统计学意义（P＜0.05）；实验组ZEB1与microRNA-200c呈负相关（r＝－0.270，P＝0.001）。结论 ZEB1在宫颈癌中表达水平较高，microRNA-200c在宫颈癌中表达水平降低，提示2者在宫颈癌的浸润和侵袭转移中可能起重要作用，2者之间的相关性提示microRNA-200c可能通过ZEB1参与宫颈癌上皮间质化过程。

Objective To investigate relationship between microRNA-200c and ZEB1 in cervical epithelial mesenchymal transition factor. Methods 50 cases diagnosed with cervical cancer whose tumor tissue were taken to be the experiment group.50 cases diagnosed with uterine myoma whose normal tissue were taken to be the control group.ZEB1 and microRNA-200c of uterine tissue were were detected.Results The average level of ZEB1 in the experimental group was significantly higher than that of the control group （P〈0.05）, and in cervical cancer, lymph node metastasis and the depth of myometrial invasion had statistically significant （P〈0.05）.In experimental group, microRNA-200c average was lower than control group （P〈0.05）, and in cervical cancer, different pathological grade group, lymph node metastasis and deep muscular layer infiltration had statistically significant（P〈0.05）.In experimental group, ZEB1 and microRNA-200c showed negative correlation（r =-0.270 P =0.001）.Conclusion The expression level of ZEB1 in cervical cancer is higher, and the expression level of microRNA-200c in cervical cancer is lower, suggesting that the two factors may play an important role in the invasion and metastasis of cervical cancer.The correlation between the two factors suggests that microRNA-200c may be involved in the process of cervical cancer by ZEB1.