中成药联合抗菌药物治疗肺癌化疗患者肺部感染的临床疗效观察

Clinical observation on TCM combined with antibiotic drugs in treatment of lung cancer patients with pulmonary infection

目的探讨中成药联合抗菌药治疗肺癌化疗患者肺部感染的临床疗效。方法选择确诊为肺癌合并肺部感染的住院患者150例随机分为治疗组和对照组各75例,2组患者均根据药敏试验结果,给予头孢唑肟1 g结合敏感抗菌药物治疗,在此基础上,治疗组给予桂龙咳喘宁片,口服,5粒/次,3次/天,2组治疗疗程均为2周。结果经过2周的不同治疗方案,治疗组的总有效率为88.0%,对照组的总有效率为73.3%,治疗组的总有效率优于对照组(P<0.05);2组的WBC、NEUT(%)及CRP均明显下降,但治疗组的改善情况优于对照组(P<0.05或<0.01);治疗组的发热缓解时间、肺部啰音消失时间、咳嗽、咳痰明显减少时间以及住院时间均少于对照组(P<0.01)。结论桂龙咳喘宁片联合抗菌药物控制肺癌化疗后肺部感染疗效明显,可明显减轻患者症状,提高有效率,减少患者住院时间。

Objective To investigate clinical effect of Guilongkechuanning capsules combined with antibiotic drugs in treating lung cancer patients with respiratory tract infection.Methods A total of 150 lung cancer patients with respiratory tract infection were randomly divided into treatment group and control group.Ceftizoxime 1g was given to all of the patients for anti-inflammatory.While Guilongkechuanning capsules were given to the treatment group only.Results After two weeks of different treatment options, the total effect rate of treatment group was 88.0%, it was 73.3% in control group, the total efficiency of treatment group was better than control group（P〈0.05）.WBC, NEUT （%） and CRP of patients in treatment group decreased significantly than control group（P〈0.05）.The time of fever relief, pulmonary rales disappearing, cough and sputum significant reducing in treatment group were less than the control group, the differences were all statistically significance （P〈0.01）.Conclusion Guilongkechuanning pill combined with antibacterial drugs in control of lung infection in the patients has obvious curative effect, can significantly reduce the symptoms of patients, improve the efficiency, reduce hospitalization time.