欧龙马滴剂联合阿奇霉素治疗儿童慢性鼻窦炎的疗效观察

Clinical observation of Sinupret Drops combined with azithromycin in treatment of chronic sinusitis of children

目的探讨欧龙马滴剂联合阿奇霉素治疗儿童慢性鼻窦炎的临床疗效。方法选取2013年7月—2014年6月昆山市第一人民医院收治的慢性鼻窦炎患儿131例,随机分为对照组（65例）和治疗组（66例）。对照组口服阿奇霉素颗粒5 mg/kg,1次/d,同时使用鼻用激素,1次/d。10 d为1个疗程,第1-6天用药,第7-10天停用。治疗组在对照组的基础上联合应用欧龙马滴剂,1个疗程为10 d,第1-5天,50滴/次,第6-10天,25滴/次,3次/d。两组均连续治疗9个疗程。观察两组的临床疗效,同时比较两组治疗前后鼻部症状、相关症状、睡眠障碍、情感结局、症状体征评分的变化。结果治疗后,对照组和治疗组的总有效率分别为87.69%、96.97%,两组总有效率比较差异有统计学意义（P〈0.05）。治疗后,两组患者鼻部症状、相关症状、睡眠障碍、情感结局、症状体征评分均较治疗前显著降低,同组治疗前后差异有统计学意义（P〈0.05）;且治疗组各观察指标的降低程度优于对照组,两组比较差异具有统计学意义（P〈0.05）。结论欧龙马滴剂联合阿奇霉素治疗儿童慢性鼻窦炎具有较好的临床疗效,能明显改善患儿的总体症状体征,改善鼻腔症状,具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Sinupret Drops combined with azithromycin in treatment of chronic sinusitis of children. Methods Patients（131 cases） with chronic sinusitis in the First People＇s Hospital of Kunshan from July 2013 to June 2014 were randomly divided into control（n=65） and treatment（n=66） groups. Patients in control group were po administered with Azithromycin Granules 5 mg/kg, once daily, and they were given nasal hormone, once daily. A period of treatment included 10 d, and the patients took drugs for 1 — 6 d, while 7 — 10 d was downtime. Patients in treatment group were given Sinupret Drops on the basis of control group, and a period of treatment included 10 d, 50 drops/time from day 1 to day 5, and 25 drops/time from day 6 to day 10, three times daily. Patients in two groups were treated for 9 courses. After treatment, the efficacy was evaluated, and the scores of nasal symptoms, associated symptoms, sleep disorders, emotional ending, signs and symptoms in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 87.69% and 96.97%, respectively, and there were differences between two groups（P〈0.05）. The scores of nasal symptoms, associated symptoms, sleep disorders, emotional ending, signs and symptoms in two groups were significantly reduced, and the difference was statistically significant in the same group（P〈0.05）. The lower levels of those observation indexes improved better than those in the control group, with significant differences between two groups（P〈0.05）. Conclusion Sinupret Drops combined with azithromycin has good effect in treatment of chronic sinusitis of children, and can obviously improve the patient＇s overall symptoms and signs, also can improve the nasal symptoms, which has a certain clinical application value.