二茂铁基查耳酮类化合物的合成及其抗乳腺癌活性研究

Synthesis of ferrocenyl chalcone compounds and their anti-breast cancer activities

目的设计并合成了二茂铁基查耳酮类化合物,并对其抗乳腺癌活性进行研究。方法通过Claisen-Schmidt缩合反应合成含有二茂铁基的查耳酮类化合物,并通过MTT法对目标化合物的抗乳腺癌活性进行研究。结果合成了9个含有二茂铁基查耳酮类化合物,其结构均通过^1H-NMR、^13C-NMR进行了表征。生物活性结果表明,目标化合物1-9对MCF-7和MDA-MB-23均具有较强的抑制活性,其中化合物6对MDA-MB-231的抑制活性最强。结论本研究为开发具有抗荷尔蒙非依赖型乳腺癌活性的查耳酮类化合物提供了参考。

Objective To design and synthesize ferrocenyl chalcone compounds, and to study their anti-breast cancer activities. Methods A series of ferrocenyl chalcones were synthesized by Claisen-Schmidt condensation reaction, and the anti-breast cancer activity was assessed by MTT method. Results Nine ferrocenyl chalcone compounds were synthesized and characterized by ^1H-NMR and ^13C-NMR. The preliminary biological results showed that target compounds 1 — 9 displayed significant inhibitory activities on both MCF-7 and MDA-MB-231 cell lines. Specifically, compound 6 showed the best inhibitory activity against MDA-MB-231. Conclusion This study provides reference for development of chalcone compounds with inhibitory activity in hormone-independent breast cancer.