摘要
目的总结胃动蛋白基因1(gastrokine 1,GKN1)在胃黏膜相关疾病中的作用及机理,探讨GKN1与胃黏膜相关疾病的关系。方法复习近年来国内外关于GKN1与胃黏膜相关疾病的研究文献以进行综述。结果GKN1的表达水平从胃炎、胃溃疡到胃癌依次逐渐下调。GKN1具有保护胃黏膜、促进黏膜修复和抑制胃癌发生发展的作用。结论 GKN1不仅可以抑制胃良性疾病向胃癌的发展,而且可以抑制胃癌的进展,这为胃癌的诊治提供了新的思路。
Objective To summarize the role and mechanism of gastrokine 1 （GKN1） in the gastric mucosal relative diseases, and to explore the relationship between GKN1 and gastric mucosal relative diseases. Methods The literatures about GKN1 and gastric mucosal relative diseases in recent years were collected to make a review. Results The expressions of GKN1 gradually declined from gastritis, gastric ulcer to gastric cancer. GKN1 had the effect of protec- ting gastric mucosa, promoting mucosal repairment, and inhibiting the progression of gastric cancer. Conclusions GKN1 not only prevents the development of gastric benign diseases to gastric cancer, but also inhibits the progression of gastric cancer, which provides a new idea for the diagnosis and treatment of gastric cancer.
出处
《中国普外基础与临床杂志》
CAS
2015年第9期1143-1147,共5页
Chinese Journal of Bases and Clinics In General Surgery
基金
四川省卫生厅科研资助项目(项目编号:120430)~~
关键词
胃动蛋白基因1
胃炎
胃溃疡
胃癌
Gastrokine 1
Gastritis
Gastric ulcer
Gastric cancer
