痰热清联合头孢曲松钠对慢性阻塞性肺疾病急性加重期的影响

Effects of Tanreqing injection combined with ceftriaxone sodium on chronic obstructive pulmonary disease with acute exacerbation

目的探讨痰热清联合头孢曲松钠对慢性阻塞性肺疾病急性加重期(AECOPD)炎性因子及内皮素的影响。方法选取78例AECOPD患者为研究对象,采用数字表法随机分为观察组和对照组各39例。对照组给予头孢曲松钠治疗,观察组采用痰热清联合头孢曲松钠治疗。观察2组治疗效果、炎性因子及内皮素水平变化。结果观察组治疗效果优于对照组(P<0.05);治疗后,2组肿瘤坏死因子(TNF-α)、细胞间黏附分子(ICAM-1)、白介素-8(IL-8)及内皮素-1(ET-1)水平均显著下降(P<0.05),观察组均明显低于对照组(P<0.05);2组降钙素基因相关肽(CGRP)水平均显著升高(P<0.05),观察组明显高于对照组(P<0.05)。结论痰热清联合头孢曲松钠有利于降低炎性因子及ET-1水平,升高CGRP含量,提高治疗效果。

Objective To study the effects of Tanreqing injection combined with ceftriaxone sodium on chronic obstructive pulmonary disease with acute exacerbation.Methods Seventy-eight patients with AECOPD were divided into observation group and control group.The control group received ceftriaxone sodium,and the observation group received Tanreqing injection combined with ceftriaxone sodium.The efficacy,the levels of inflammatory factors and endothelin were compared between two groups.Results The clinical efficacy of observation group was significantly better than that of control group.After treatment,the levels of TNF-α,ICAM-1,IL-8,ET-1 were significantly decreased in both groups（P〈0.05）,and especially in the observation group（P〈0.05）.The level of CGRP was significantly increased in both groups（P〈0.05）,and especially in the observation group（P〈0.05）.Conclusions Tanreqing injection combined with ceftriaxone sodium help reduce the levels of inflammatory factor and endothelin,and improve the effect of treatment.