甲状腺全切术联合放射性碘治疗甲状腺癌的临床疗效观察

Observation on the clinical effect of combination of thyroidectomy and radioactive iodine treatment in patients with thyroid carcinoma

目的探讨甲状腺全切术联合放射性碘治疗甲状腺癌的临床疗效以及对患者生命质量的影响。方法选取符合纳入标准的甲状腺癌患者93例,分为试验组47例和对照组46例。两组均予以甲状腺全切术治疗,试验组在此基础上予以术后放射性碘治疗。比较两组的临床疗效、患者的生命质量。结果试验组有效率为87.24%,明显高于对照组有效率71.74%,差异具有统计学意义(P<0.05)。试验组情绪功能、总健康状况明显高于对照组(80.32±14.75 vs.77.60±11.58;83.33±16.24 vs.63.83±12.03,P<0.01);试验组疲倦评分明显低于对照组(12.75±15.20 vs.21.33±13.56,P<0.01)。其余各项比较差异无统计学意义。结论甲状腺全切术联合放射性碘治疗甲状腺癌不仅提高临床疗效,同时提高患者生命质量,值得临床推广。

Objectine To explore the clinical effect of combined thyroidectomy with radioactive iodine treatment in patients with thyroid carcinoma and to observe its influence on the quality of life of patients. Methods A total of 93 patients with thyroid carcinoma met the inclusion criteria were allocated in this study,and they were divided into two groups：trial group,（47 cases）and control group（46 cases）. Patients in these two groups were treated with total thyroidectomy,and patients in trial group were additionally treated with radioiodine therapy. The quality of life and clinical curative effect of patients in these two groups were compared. Results The effective rate in trial group was 87. 24% ,that in con-trol group was 71. 74% ,and the difference was statistically significant（ P ﹤ 0. 05）. The emotional function and health status of patients in trial group were higher than those of patients in control group（80. 32 ± 14. 75 vs. 77. 60 ± 11. 58;83. 33 ± 16. 24 vs. 63. 83 ± 12. 03,P ﹤ 0. 01）. The fatigue scores of patients in trial group were lower than those of patients in control group（12. 75 ± 15. 20 vs. 21. 33 ± 13. 56,P ﹤ 0. 01）. The difference in other items showed no statistical significance. Conclusion Combined therapy can enhance its clinical efficacy,and it may also im-prove the quality of life of these patients,hence it is worthy to be applied for clinical promotion.