摘要
桥粒是细胞间连接的主要方式，对维持上皮组织的正常形态和功能具有重要意义。桥粒胶糖蛋白（DSC）为钙粘蛋白超家族成员之一，与桥粒芯糖蛋白（DSG）合称为桥粒钙粘素（DC），是组成桥粒的重要蛋白成分。人类桥粒钙粘素基因位于18号染色体长臂1区2带，表达 DSC1-3与 DSG1-4两组蛋白［1］。与传统的钙粘素相似，DC 具有完整的跨膜糖蛋白结构，其胞外部分包含氨基酸识别序列，以异二聚体的形式完成细胞间桥粒连接；而胞内区与胞浆内的附着板相连，进而连接细胞骨架的角蛋白成分。
出处
《临床和实验医学杂志》
2015年第18期1572-1574,共3页
Journal of Clinical and Experimental Medicine
基金
北京市自然科学基金项目
北京市教育委员会科技计划重点项目(项目编号:KZ201410025024)
北京市卫生系统高层次卫生技术人才培养计划项目(项目编号:2014-3-003)
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