血清Cys-C对急性心肌梗死患者PCI术后生存状况的影响

The effect of Cys-C on living condition of PCI Post-surgical survival of AMI patients

目的探究血清Cys-C水平对急性心肌梗死患者接受直接冠状动脉介入(PCI)术后生存状况的影响。方法选取2012年3月至2013年9月期间在陕西商洛市中心医院行急诊PCI术的首发性急性心肌梗死(AMI)患者171例,记录患者的一般临床资料,测定患者入院当天的血清Cys-C的含量,通过对血清Cys-C水平的高低分为高血清Cys-C组87人和正常血清Cys-C组84人,观察两组患者PCI术后的泵衰竭程度、入院病死率、心血管事件发生率,左心室射血分数和生存质量(QOL)。结果高血清Cys-C组肾衰竭程度Killip分级、入院病死率和心血管事件发生率[(1.8±1.1);24.14%;16.73%]高于正常血清Cys-C组[(1.0±0.6);2.38%;3.88%],差异均具有统计学意义(P<0.05)。高血清Cys-C组的左室射血分数(51.87±11.93)%低于正常血清Cys-C组(59.21±11.36)%,差异有统计学意义(P<0.05),高血清Cys-C组生存质量低于正常血清Cys-C组(P<0.05)。结论血清Cys-C水平的升高增加AMI患者PCI术后泵衰竭程度和入院病死率,影响心脏功能,降低患者的生存质量。

Objective To observe the effect of Cys-C in reducing quality of life for acute myocardial infarction（AMI）patients after percutaneous coronary intervention（PCI） operation. Methods 171 patients with first AMI were included in our hospital from March 2012 to September 2013. They were assigned to normal Cys-C group（n=84） and high Cys-C group（n =87） accordin g to their concentration of Cys-C. The general data, hospital mortality, LVEF, MACE, HF and QOL were compared between the two groups. Results The percentages of HF（1.8 ±1.1）, hospital mortality（24.14%）,MACE（16.73%）in high Cys-C group were significant higher than those in normal Cys-C group [（1.0 ±0.6）; 2.38%;3.88%]（P〈0.05）. The LVEF was significant different between normal Cys-C group and high Cys-C group [（51.87±11.93）%vs（59.21±11.36）%]（P〈0.05）. And there was significant difference in QOL（P〈0.05）. Conclusions Cys-C has positive correlation with HF, hospital mortality, MACE and negative correlation with QOL and may affect the cardiac function.