跨血脑屏障靶向递药系统研究进展

Targeting drug delivery system through blood-brain barrier

脑组织局部及相关疾病的药物治疗一直是一个难题,由于血脑屏障的存在,一方面保护了脑组织免于各种有害物质的损伤,但另一方面也增加了药物到达治疗部位的难度。随着脑部疾病发病率增加,加上其较高的致残率和致死率,药物的脑靶向递送成为目前研究的一个热点。本文主要综述近年来药物脑靶向递送相关领域的研究进展。

Due to the presence of blood-brain barrier, the treatment of brain related diseases by drug delivery is challenging. On the one side, the blood-brain barrier protects the brain from injury of some harmful substances, on the other side, the barrier also increases the difficulty for drug delivery. With the increase of brain diseases, and its high mutilation rate and fatality rate, brain targeting drug delivery system has become a heated research field. This paper mainly summarized the recent research progress in targeting drug delivery system.