齐拉西酮与利培酮对精神分裂症患者的疗效及其对血糖血脂的影响

Comparative study of curative effect and blood glucose and lipid in schizophrenic patients who treated with ziprasidone and risperidone

目的观察齐拉西酮与利培酮对精神分裂症患者的治疗效果及其对血糖、血脂的影响。方法将96例精神分裂症患者随机分为采用齐拉西酮治疗的齐拉西酮组与采用利培酮治疗的利培酮组,共治疗8周,于基线水平(治疗前)、治疗第4周末和第8周末分别对患者的血糖、血脂进行测定。结果两组治疗前阳性和阴性症状量表(PANSS)阳性症状评分、阴性症状评分比较,差异无统计学意义(P>0.05)。两组治疗第4、8周评分与基线评分比较均显著下降,差异均有统计学意义(P<0.05),而两组间比较差异无统计学意义(P>0.05)。治疗8周后,齐拉西酮组有效率为91.7%,利培酮组有效率为89.6%,两组间比较差异无统计学意义(P>0.05)。齐拉西酮组治疗后血脂、血糖水平与基线水平比较差异无统计学意义(P>0.05)。利培酮组治疗后血脂、血糖水平增加明显,与基线水平比较差异有统计学意义(P<0.05)。结论齐拉西酮与利培酮治疗精神分裂症疗效相当。齐拉西酮对精神分裂症患者的血糖、血脂无明显影响,而利培酮可升高血糖、血脂,长期服用需注意其副作用。

Objective To observe the effects of ziprasidone and risperidone on patients with schizophrenia and their influence on bloodglucoseandlipids.Methods 96patientswithschizophrenicenrolledinthestudywererandomlydividedintotwogroups,zi‐prasidone and risperidone group ,and both were treated for 8 weeks .Their blood glucose ,blood lipid of base line and at the end of the 4th ,8th week were determined respectively .Results The positive and negative symptoms scores of the two groups by using Positive and Negative Syndrome Scale（PANSS） before and after treatment were not statistically different（P〉 0 .05） .Compared with the baseline scores ,scores at the end of 4th and 8th week in both ziprasidone and risperidone groups significantly decreased（P〈0 .05） ,but there was no statistically significant difference between the two groups（P〉0 .05） .After 8 weeks′ treatment ,the ef‐fective rate was 91 .7% in ziprasidone groups and 89 .6% in risperidone group .There were no significant differences between the two groups（P〉0 .05） .The blood lipids and glucose levels were less increased after ziprasidone treatment ,but was not statistically significant（P〉0 .05） .The blood lipids and glucose levels significantly increased after risperidone treatment（P〈0 .05） .Conclusion Ziprasidone and risperidone had the same effect on schizophrenia .Ziprasidone had no effect on blood glucose and lipids in schizo‐phrenic patients ,while risperidone could increase blood glucose and lipids level ,we should pay attention to the side effects of long‐term use .