老年冠心病患者血浆超氧化物歧化酶水平变化的相关因素分析

Analysis of related factors of superoxide dismutase level changes in elderly patients with coronary heart

目的探讨影响老年冠心病患者血浆超氧化物歧化酶(SOD)水平变化的相关因素。方法选取该院收治的老年冠心病患者232例,将血浆SOD≥129U/mL的患者设为A组,血浆SOD<129U/mL的患者设为B组,观察比较两组患者各检测指标的差异。结果两组患者在年龄、C反应蛋白(CRP)、血栓素B2(TXB2)和血浆6-酮-前列环素F1a(6-Keto-PGF1a)方面比较,差异有统计学意义(P<0.05),而在性别构成、丙氨酸氨基转移酶(ALT)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、总胆固醇(TC)、血肌酐(Cr)及同型半胱氨酸(Hcy)方面比较,差异无统计学意义(P>0.05);两组患者在脑卒中、细菌性肺炎/慢性支气管炎急性发作的比例方面比较,差异有统计学意义(P<0.05),在高血压、2型糖尿病、恶性肿瘤的发生比例方面比较,差异无统计学意义(P>0.05);非条件性Logistic回归结果显示:老年冠心病患者血浆SOD降低的主要因素为年龄增加、CRP升高、TXB2升高、6-Keto-PGF1a降低、脑卒中、细菌性肺炎/慢性支气管炎急性发作。结论高龄、CRP升高、TXB2升高、6-KetoPGF1a降低、脑卒中、细菌性肺炎/慢性支气管炎急性发作是老年冠心病患者血浆SOD降低的影响因素。

Objective To explore the related factors of plasma superoxide dismutase （SOD） levels in elderly patients with coro‐naryheartdisease.Methods 232elderlypatientswithcoronaryheartinthehospitalwereenrolledinthestudy,thepatientswhose plasma SOD≥129 U/mL were included as group A ,plasma SOD levels 〈129U /mL were divided into group B ,the difference ob‐served two groups were compared for each observation indicators .Results The two groups in age ,CRP ,TXB2 ,6‐Keto‐PGF1a were statistically significant different（P〈0 .05） ,while in the gender composition ,ALT ,TG ,HDL ,LDL ,TC ,Cr ,Hcy was no significant difference（P〉0 .05）;the proportion of patients with stroke ,bacterial pneumonia/acute exacerbation of chronic bronchitis in the two groups were statistically significant different（P〈0 .05）;in the proportion of hypertension ,type 2 diabetes ,cancer was no statistical‐ly significant difference（P〉0 .05）;Non conditional Logistic regression results shown that the main factors that led to the decrease of SOD in elderly patients with coronary heart disease were age increase ,CRP increase ,TXB2 increase ,6‐Keto‐PGF1a decrease , stroke ,bacterial pneumonia/acute exacerbation of chronic bronchitis .Conclusion Old age ,elevated CRP ,elevated TXB2 ,decreased 6‐Keto‐PGF1a ,stroke ,bacterial pneumonia/acute exacerbation of chronic bronchitis are the factors leading to the decrease of plasma SOD in aged patients with coronary heart disease .