枳术宽中胶囊联合质子泵抑制剂治疗反流性食管炎临床观察

Clinical study of Zhizhukuanzhong capsule combined with proton pump inhibitors on the treatment of reflux esophagitis

[目的]观察枳术宽中胶囊联合质子泵抑制剂(PPI)治疗反流性食管炎的临床效果。[方法]将100例反流性食管炎患者随机分为观察组和对照组,每组50例。对照组给予奥美拉唑和西沙必利联合治疗(PPI治疗),奥美拉唑每次20mg,2次/d;西沙必利每次10mg,3次/d,餐前或者睡前服用。观察组在对照组的治疗基础上加服枳术宽中胶囊1.29g,口服,3次/d。比较2组治疗前、后临床症状及治疗8周后的临床疗效。[结果]经治疗,2组患者临床症状均较治疗前明显缓解。治疗4周后,2组患者的烧心症状积分比较,差异无统计学意义(P>0.05),观察组的反酸和胸骨后疼痛症状积分明显优于对照组(P<0.01);治疗6周、8周以及停药2周后,观察组的反酸、烧心、胸骨后疼痛症状均优于对照组,差异有统计学意义(P<0.01);观察组疗效明显优于对照组,差异有统计学意义(P<0.05)。[结论]枳术宽中胶囊联合PPI治疗反流性食管炎安全有效,且无明显不良反应,值得临床推广。

[Objective]The clinical efficacy of Zhizhukuanzhong capsule combined with proton pump inhibitors（PPIs）therapy on 50 cases of reflux esophagitis were observed.[Methods]One hundred cases of reflux esophagitis in our hospital were randomly divided into observation group and control group with 50 cases in each group.The cases in control group received omeprazole and cisapride combination therapy.The cases in observation group received an additional Zhizhukuanzhong capsule treatment.A course of treatment in both groups were 8weeks.The clinical efficacy of two groups were compared.[Results]The clinical symptoms were significantly alleviated.The difference of symptoms scores of acid reflux,heartburn,chest burning before treatment was not statistically significant（P 〉0.05）in both groups.After 4weeks treatment,the symptom score of heartburn was not different between the two groups.The symptom scores of acid reflux and chest pain in the observation group was significantly lower than the control group.At the 6weeks,8weeks and 2weeks after discontinuation,the symptoms scores of acid reflux,heartburn,chest pain in observation group were significantly lower than the control group（P 〈0.01）.[Conclusion]Zhizhukuanzhong capsule combined with PPI shows safe,effective,and no significant adverse reactions on the treatment of reflux esophagitis,which is worthy of promotion.