TSP-1与BMP-7在慢性鼻-鼻窦炎鼻黏膜组织中的表达及意义

Expression and significance of TSP-1 and BMP-7 in nasal mucosa of chronic rhinosinusitis

目的观察血小板反应蛋白-1(TSP-1)、骨形态发生蛋白-7(BMP-7)在慢性鼻-鼻窦炎(CRS)患者鼻黏膜组织中的表达变化,探讨其在CRS发病机制中的意义。方法采用酶联免疫吸附方法检测TSP-1、BMP-7及转化生长因子β1在鼻黏膜组织中的含量变化。结果随着CRS不伴鼻息肉型患者分期的增高,TSP-1和TGF-β1水平逐渐升高(P<0.05),BMP-7水平逐渐下降(P<0.05)。随着CRS伴鼻息肉型患者分期的增高,TSP-1和TGF-β1水平均明显下降(P<0.05),BMP-7水平均明显升高(P<0.05)。结论 TSP-1与BMP-7在CRS中表达异常,可能在CRS发病机制中发挥作用。

Objective To explore the expression of thrombospondin-1 （TSP-1 ）and bone morphogenetic protein-7 （BMP-7） in mucus membrcane of chronic rhinosinusitis （CRS） and its potential significance in pathogenesis. Methods TSP-1, BMP-7 and TGF-[M were detected by ELISA. Results The expression level of TSP-1 and TGF- 131 increased gradually with the advanced stage of CRSsNP（P 〈 0. 05 ）. The expression of BMP-7 decreased gradu- ally with the advanced stage of CRSsNP （P 〈 0. 05 ）. The expression of TSP- 1 and TGF-[31 decreased gradually with the advanced stage of CRSwNP（P 〈 0. 05 ）. The expression level of BMP-7 increased gradually with the ad- vanced stage of CRSwNP（P 〈 0. 05 ）. Condusions The expressions of TSP-1 and BMP-7 were abnormal in nasal mucosa of CRS, which might be involved in the pathogenesis of CRS.