正常及退变软骨T1弛豫值及T2弛豫值的定量研究

Study of T1 Relaxation Time and T2 Relaxation Time in Patella Cartilage of Normal and Early Osteoarthritis

目的:探讨正常及退变软骨磁共振T1驰豫值及T2弛豫值的定量研究价值。方法:采用PHILIPS Acheiva 3.0超导型磁共振仪进行T1弛豫值及T2弛豫值的定量测定,选择60例正常及退变膝关节,其中正常组(n=20)、OA(退行性骨关节炎,osteoarthritis)组(n=40);OA组按照kellgren-Lawrence评分又分为轻度OA组(n=20)、中度OA组(n=11)及重度0A组(n=9)。结果:正常组、轻度OA组、中度OA组、重度OA组平均T2驰豫值分别为(39.31±3.9)ms、(48.58±8.53)ms、(54.92±8.84)ms、(59.03±6.30)ms;采用协方差分析,协变量年龄对T2值有明显的影响(F=5.745,P=0.018<0.05);四组髌软骨T2值有明显差异(F=26.579,p=0.00<0.05)。正常组、轻度OA组、中度OA组、重度OA组平均T1弛豫值分别为(511.70±72.25)ms、(458.03±55.89)ms、(405.89±57.30)ms、(357.92±36.74)ms。采用单因素方差分析,四组T1弛豫值有明显的差异(F=17.70,P=0.00<0.05)。结论:T2弛豫值、T1弛豫值随着退变程度的加重发生明显变化,其定量分析在早期OA诊断中有较高的临床应用价值。

Purpose： To evaluate the diagnostic value of T1 relaxation time and T2 relaxation time in patella cartilage of asymptomatic volunteers and osteoarthritis （OA）. Methods： Quantitative T1 relaxation time and T2 relaxation time of patella cartilage from 60 people were evaluated on a 3.0T MR scanner. The study population was categorized as normal group （n-20） and OA group （n=40）. And the OA group was stratified by kellgren- Lawrence into 3 cohorts： mild OA group （n=20）, moderate OA group （n=ll） and severity OA group （n=9）. Results： The average T2 relaxation time of patella cartilage in normal, mild OA, moderate OA and severity OA group were （39.31±3.9） ms, （48.58±8.53） ms, （54.92±8.84） ms, （59.03±6.30） ms. respectively; there were significant differences of average T2 relaxation time among these four groups （F=26.579, P=0.00〈0.05） and age had an effect on T2 relaxation （F=5.745, P=0.018〈0.05） by covariance analysis. The average T1 relaxation of patella cartilage in normal group, mild OA, moderate OA and severity OA group were （511.70±72.25） ms, （458.03±55.89） ms, （405.89±57.30） ms, （357.92±36.74） ms, respectively; there were significant differences of average T1 relaxation time among these four groups （F=17.70, P=0.00〈0.05）. Conclusion： The study of T2 relaxation time and T1 relaxation time of patella cartilage could indicate component abnormality of articular cartilage at the degree of early OA, and had a high value in early OA diagnosis.