维吾尔族和汉族前列腺癌骨转移患者氯化锶疗效的研究

Effect of 89SrCl2 for bone metastasis in Uygur and Han patients with prostate cancer

目的 对比分析维吾尔族和汉族前列腺癌骨转移患者氯化锶（89SrCl2）治疗的效果.方法 75例维吾尔族和82例汉族前列腺癌骨转移患者静脉注射89SrCl2后,观察其镇痛效果,单光子发射计算机断层成像术（SPECT）监测骨转移灶,电化学发光法测定前列腺特异性抗原（PSA）和白细胞介素-6（IL-6）的变化.结果 89SrCl2治疗后,维吾尔族患者镇痛有效率为82.67％（62/75）,高于汉族患者的60.98％（50/82）（P＜ 0.05）;维吾尔族患者骨转移灶治疗有效率74.67％（56/75）,高于汉族患者的52.44％（43/82）（P＜0.05）;维吾尔族患者IL-6降低水平为（4.24±1.74） pg/ml,高于汉族患者的（2.81±2.38）pg/ml（P＜ 0.05）.结论 89SrCl2治疗维吾尔族前列腺癌骨转移患者比治疗汉族患者疗效更好,临床应加以重视。

Objective To analyze contrastly the effect of 89SrCl2 for bone metastasis in Uygur and Han patients with prostate cancer.Methods The curative effects in 75 Uygur and 82 Han patients with prostate cancer bone metastasis were investigated after intravenous injection with 89SrCl2,including palliation of pain.SPECT was used to detect the change of metastasis,level of prostate-specific antigen （PSA） and interleukin-6 （IL-6） were detected by electrochemiluminescence immunoassay.Results After treated with 89SrCl2,the palliation rate,the bone metastases and the level of IL-6 were higher in Uygur patients [82.67 % （62/75）,75 % （56/75）,（4.24±1.74） pg/ml] than those in Han patients [60.98 % （50/82）,52.44 % （43/82）,（2.81±2.38） pg/ml],and there were statistically significant （P 〈 0.05）.Conclusion 89SrCl2 is more effective for the Uygur patients with prostate cancer bone metastasis than the Han patients,clinical workers should pay more attention to this.