摘要
蛋白编码转录组和假基因、长链非编码RNA和环形RNA等非编码转录组共同组成了竞争性内源RNA（ceRNA）.ceRNA之间通过miRNA应答元件进行“对话”,竞争性结合miRNA,调节基因的转录后表达.越来越多的研究发现,ceRNA通过拮抗效应隔离miRNA,形成一个广泛的基因转录后调节网络,参与正常生理状态的维持及对肿瘤等疾病的发生、发展过程的调控.ceRNA对肿瘤进程的调控可分为正性调控及负性调控,结果因其所影响的miRNA种类及细胞类型而异.ceRNA对肿瘤进程的调控作用使其可能成为肿瘤临床诊治的新靶点。
Protein-coding transcriptome,pseudogenes,long non-coding RNAs and circular RNAs can act as competing endogenous RNA （ceRNA）.ceRNA can crosstalk with each other through microRNA recognition elements （MRE）,thus regulating the post-transcriptional gene expression.More and more evidences showed that ceRNA could form an extensive network of post-transcription regulation,keep the cell homeostasis and involve in the disease development and progression like tumorigenesis and cancer progression.Depending on up-regulation or down-regulation of different kinds of microRNA in different cells,ceRNA acts as either an oncogene or a tumor suppressor.ceRNA may have a great potential in cancer diagnosis and treatment.
出处
《肿瘤研究与临床》
CAS
2015年第8期568-571,共4页
Cancer Research and Clinic
基金
国家自然科学基金面上项目（81172030）
上海交通大学医学院大学生创新性实验项目（2014059）
关键词
竞争性内源RNA
微小RNA
肿瘤进程
竞争性内源RNA
微小RNA
Competing endogenous RNA
microRNA
Cancer progression
