改性大豆油的亚慢性毒性研究

Study on the subchronic toxicity of salatrim

目的通过大鼠90 d喂养实验,了解改性大豆油(salatrim)的亚慢性毒性,对其安全性做出评价。方法试验设3个试验组、1个阴性对照组。单笼饲养,每天观察并记录动物的一般表现、中毒表现和死亡情况。每周记录1次体重和2次食物摄入量,计算每周及总的食物利用率。连续灌胃90 d,每周记录体重及摄食量,灌胃结束后,做血液学、病理学等检查。结果大鼠90 d喂养试验:临床检查、血液细胞学检查、血液生化学检查、脏器称量结果表明各检验项目的实验组与对照组比较,差异无统计学意义。组织病理学检查结果表明对照组和高剂量实验组雌性、雄性大鼠的肝、肾、胃、肠、脾、睾丸、卵巢均未见与试验用样品有关的组织病理学改变。结论通过各项指标的观察,未见实验样品对雌性、雄性大鼠有明显毒性作用。

Objective To study the subchronic toxicity of modified soybean oil（ salatrim） by 90 d feeding test and evaluate its safety. Methods 3 test groups and 1 negative control groups were set up and were fed in single cage,the general performance,poisoning and death of the animals were observed and recorded every day. The body weight was recorded once and the food intake was recorded twice every week,the weekly and total food utilization were calculated. The weight and food intake per week were recorded with 90 d continuous gavage. After the end of gavage,the blood,pathology,and so on were examined. Results The90 d feeding test： No statistical significance was found in all the indexes of test group and control group about clinic examine,hematology indexes,biochemical indexes,weight of viscera. This topathological examination showed that the liver,kidney,stomach,intestine,spleen,testis and ovary of the rats in the control group and the high dose group were not associated with the pathological changes of the test sample. Conclusion Through the study on the indexes of test,There are no obvious toxic effects on the male and female rats.