视黄醇结合蛋白在急性肝炎、重症肝炎和肝硬化中的诊断价值

Diagnostic value of retinol binding protein in patients with acute hepatitis,severe hepatitis and live cirrhosis

目的探讨视黄醇结合蛋白在急性肝炎、重症肝炎和肝硬化中的诊断价值。方法收集2012年1月-2014年7月本院感染科、消化内科的住院患者90例,按不同疾病类型分为急性肝炎组(30例)、重症肝炎组(30例)、肝硬化组(30例)。分别在患者入院时及出院时测定视黄醇结合蛋白和血白蛋白。结果 3组患者入院时及出院时视黄醇结合蛋白分别为22.3 mg/L±11.2 mg/L、36.7 mg/L±16.5 mg/L;16.8 mg/L±7.9 mg/L、25.3 mg/L±12.4 mg/L;11.5 mg/L±6.8 mg/L、16.9 mg/L±8.2 mg/L,各组患者入院时及出院时视黄醇结合蛋白比较,差异有统计学意义(P<0.05),3组患者出院时血白蛋白水平较入院时明显提高,差异具有统计学意义(P<0.05)。结论视黄醇结合蛋白能够较好的反应急性、重症肝炎和肝硬化病情程度,治疗后患者视黄醇结合蛋白水平明显提高,与疾病恢复同步,具有较好的临床诊断价值与预后价值。

Objective Study on the diagnostic value of retinol binding protein in patients with acute hepatitis,severe hepatitis and live cirrhosis. Methods From January 2012 to July 2014,90 cases of patients in infectious department and department of gastroenterology in our hospital were collected. According to patients with different disease types,all of these patients were divided into acute hepatitis group（ 30 cases）,severe hepatitis group（ 30 cases） and liver cirrhosis group（ 30 cases）. The retinol binding protein and albumin were detected among the groups on admission and discharge. Results The level of retinol binding protein in the 3 groups on admission and discharge was 22. 3 mg / L ± 11. 2 mg / L,36. 7 mg / L ± 16. 5 mg / L; 16. 8 mg / L ±7. 9 mg / L,25. 3 mg / L ± 12. 4 mg / L; 11. 5 mg / L ± 6. 8 mg / L,16. 9 mg / L ± 8. 2 mg / L,the differences had statistical significance in these 3 groups on admission and discharge（ P〈0. 05）; Plasma albumin level in these 3 groups was markedly elevated on discharge and the differences had statistical significance（ P〈0. 05）. Conclusion Retinol binding protein can reflect the severity of acute hepatitis,severe hepatitis and liver cirrhosis severity,after active treatment,retinol binding protein level was significantly increased,so detection of these two proteins had a high diagnostic value and prognostic value.