柳州市人群高尿酸血症流行现状及影响因素

Analysis on prevalence and influence factors of hyperuricemia among residents in Liuzhou

目的明确柳州市20岁以上人群高尿酸血症(HUA)的患病率及其影响因素。方法对51 206名体检居民进行横断面调查,运用Logistic多元回归模型对与高尿酸血症相关的人口学特征及临床指标进行分析。结果该人群中男性高尿酸血症患者10 722例,占39.5%;女性患者3 459例,占14.4%。Logistic多元回归模型统计显示,男性、高胆固醇血症、血高密度脂蛋白胆固醇降低、血肌酐升高、血尿素氮升高、血胱抑素C升高、血谷丙转氨酶升高、血γ-谷氨酰转移酶升高与高尿酸血症的患病率升高相关,而高密度脂蛋白胆固醇降低与高尿酸血症的患病率升高相关。结论柳州市人群高尿酸血症的发病率较高;男性、高胆固醇血症、血肌酐升高、血尿素氮升高、血胱抑素C升高、血谷丙转氨酶升高、血γ-谷氨酰转移酶升高可能是高尿酸血症的危险因素,高密度脂蛋白胆固醇升高可能是其保护因素。

Objective To investigate the prevalence of hyperuricemia and its risk factors in the general adult population older than 20 years old in Liuzhou. Methods 51 206 residents from Liuzhou,whose physical examinations were conducted a cross-sectional survey. Data were analyzed by multivariate logistic regression models,and analyzed the demographic characteristics and clinical indicators of hyperuricemia. Results In this group,there were 10 722 cases of male patients with hyperuricemia,accounting for 39. 5%; 3 459 cases of female patients,accounting for 14. 4%. Logistic multiple regression model showed that men,the decrease of high cholesterol,blood high density lipoprotein cholesterol,the increase of serum creatinine,blood urea nitrogen,serum cystatin C levels,elevated serum alanine aminotransferase levels,serum γ- glutamyl transferase were related to the prevalence of hyperuricemia,while the decrease of high density lipoprotein cholesterol was related with the increase of the prevalence of hyperuricemia. Conclusion The hyperuricemia prevalence rate is relatively high in Liuzhou. For male,the decrease of high cholesterol,blood high density lipoprotein cholesterol,the increase of serum creatinine,blood urea nitrogen,serum cystatin C levels,elevated serum alanine aminotransferase levels,serum γ- glutamyl transferase were the risk factors of hyperuricemia; the decrease of high density lipoprotein cholesterol may be the protective factor.