丝裂原活化蛋白激酶信号通路与白血病的研究新进展

Research progress of mitogen-activated protein kinase signaling pathways in leukemia

丝裂原活化蛋白激酶（MAPK）信号通路可参与凋亡、分化、自噬等多种细胞活动,人类细胞中主要有细胞外信号调节激酶（Erk）、p38 MAPK、c-Jun N端激酶（JNK）3条通路,每条信号通路都具有高度特异性,有其独立的功能.MAPK信号通路与白血病的发生、发展密切相关,其对白血病细胞的作用主要通过与细胞凋亡、介导细胞耐药、调控细胞自噬分化等方面有关.现就MAPK信号通路与白血病的相关研究进展进行综述.

Mitogen-activated protein kinase （MAPK） signaling pathways may be involved in various activities of cells such as apoptosis,differentiation and autophagy.In human cells,MAPK signaling pathways mainly contain Erk,p38 MAPK and JNK,and each of them is highly specific and has its own function.MAPK signaling pathways are closely related to the development of leukemia.The effect of MAPK signaling pathways on leukemia cells is mainly mediated by affecting cell apoptosis,cell drug resistant,cell autophagy and differentiation.In this review,recent advances on the study of MAPK in leukemia are reviewed.