拉曼光谱法快速测定注射用头孢他啶溶液的含量

Quantitative Determination of Ceftazidime Injections by Raman Spectroscopy

目的:建立拉曼光谱法测定注射用头孢他啶溶液含量的方法。方法:采用主成分回归法(PCR)及偏最小二乘法(PLS)结合光谱预处理方法建立定量分析模型。结果:PCR法和PLS法结合一阶导数光谱建立的定量模型较为理想,相关系数(Corr.Coeff.)分别为0.9994和0.9995,交叉验证均方差(RMSECV)分别为2.33和2.13。结论:拉曼光谱结合多元回归分析(PCR和PLS)可用于注射用头孢他啶溶液的含量测定。

Objective： To establish a Raman spectroscopy method for the content determination of ceftazidime injections. Methods： The principal component regression （PCR） and partial least square （PLS） were employed to establish the calibration models. Results： The Corr. Coeff. values of the PCR and PLS regression model were 0.9994 and 0.9995, while the root mean square error of cross validation （RMSECV）values were 2.33 and 2.13, respectively. Conclusion： PCR and PLS can be applied to the quantitative determination of ceftazidime injections.