摘要
目的通过横断面调查新诊断的2型糖尿病患者,寻找并发糖尿病肾病的危险因素,为临床早期干预糖尿病肾病提供科学依据。方法选取初发2型糖尿病患者120例,分为正常白蛋白尿组(NUA1b)和糖尿病肾病组(DN)。测定身高、体重、血压、肝肾功能、血糖、血脂、尿酸、糖化血红蛋白和胰岛素浓度。结果 DN组Hb A1C、TG、Cr、UA、FBG、PBG、Ln HOMA-IR均高于NUA1b组;Ln UACR与Ln HOMA-IR、PBG、FBG、Cr、TG呈正相关;多元逐步回归分析显示,FBG、Cr、TG和Ln HOMA-IR是独立的影响因子。结论早期发现高血糖、血脂异常和胰岛素抵抗,对糖尿病肾病的发生具有预警作用。
Objective Cross-sectional survey to analyze the incidence and risk factors of microalbuminuria in newly diagnosed type 2 diabetes patients,and to provide the theoretical basis for therapy of diabetes nephropathy. Method One hundred and twenty patients with newly diagnosed type 2 diabetes mellitus were enrolled. Subjects were divided into two groups according urine albumin-to-creatinine ratio（ UACR） ： normoalbuminuria（ NUA1b） group and diabetic nephropathy（ DN） group. All subjects were measured height,weight,blood pressure,hepatic and renal function,uric acid（ UA）,lipid profile,insulin and Hb A1 c. Result Hb A1c、triglyceride（ TG） 、creatinine（ Cr） 、UA、fasting blood gluose（ FBG） 、postprandial blood glucose（ PBG） 、HOMA- IR were significantly higher in DN group than in NUA1 b group（ Hb A1c： [8. 2 ± 2. 9]% vs [7. 8 ± 2. 1]%,P〈0. 05; TG： [5. 36 ± 3. 62]mmol / L vs [1. 57 ±0. 86]mmol / L,P〈0. 05; Cr [86 ± 39] μmol / L vs [71 ± 16]μmol / L,P〈0. 05; UA [332 ± 77] μmol / L vs[295 ± 82]μmol/L,P〈0. 05; FBG[10. 4 ± 4. 7]mmol/L vs[8. 3 ± 2. 9]mmol/L,P〈0. 05; PBG[15. 4 ± 7. 6]mmol / L vs [11. 9 ± 4. 7]mmol / L,P〈0. 05; HOMA- IR [1. 41 ± 0. 60] vs [1. 01 ± 0. 73],P〈0. 05）. There existed positive correlation between UACR and HOMA- IR（ r = 0. 247,P〈0. 05） 、PBG（ r = 0. 231,P〈0. 05） 、FBG（ r = 0. 249,P〈0. 01） 、Cr（ r = 0. 387,P〈0. 01） 、TG（ r = 0. 396,P〈0. 01）. Stepwise multiple regression analysis revealed that FBG、Cr、TG and HOMA- IR were independently risk factors of microalbuminuia. Conclusion Hyperglycemia,insulin resistance and abnormal lipid profile,maybe the risk factors of diabetic nephropathy.
出处
《中国临床医生杂志》
2015年第9期20-22,共3页
Chinese Journal For Clinicians
基金
国家临床重点专科建设项目(WBYZ2011873)
