2型糖尿病患者口服降糖药物治疗模式及血糖控制水平的影响因素研究

Research of the Medication Patterns of Oral Hypoglycemic Agents and Influencing Factor on the Levels of Blood Glucose

通过回顾分析河北医科大学第一医院门诊接诊的178例2型糖尿病患者的问卷资料,将患者分为血糖达标组和血糖未达标组,进行血糖达标影响因素分析。我院口服降糖药物主要以双胍类(32.58%)、磺脲类(24.16%)、噻唑烷二酮类(17.42%)为主,2种药物联合是主要联用方法,以磺脲类联合双胍类最常用,1年调整给药方案约占57.3%,主要原因为效果差,糖化血红蛋白达标率为54.49%。单因素分析及多因素Logistic回归分析表明,体质量指数升高(P=0.016,OR=1.044)、饮食控制(P=0.024,OR=0.471)、运动控制(P=0.005,OR=0.421)、健康教育(P=0.008,OR=4.031)、文化程度低(P=0.014,OR=1.225)是影响血糖达标的因素。

This article did a retrospective analysis of the questionnaire data of 178 patients with type 2 diabetes from the First Hospital of Hebei Medical University. All patients were divided into blood glucose well-controlled group and blood glucose inadequately-controlled group,the relation of blood glucose and influening factor were analyzed. The mainly oral hypoglycemic drugs in our hospital were biguanide （32. 58%）, sulphonylureas （24. 16%）, thiazolidinediones ketones （17.42 %）. Combination therapy of two kinds of hypoglycemie drugs was the main joint method, and the method contained sulfonylurea with metformin was the most commonly used dosing regimens, the rate of regimen adjustment within 1 year were 57.3% because of poor effect, the glycosylated hemoglobin compliance rate was 54.49%. The BMI increased （P= 0.016, OR= 1. 044）, diet control （P=0. 024, OR=0. 471）, exercise control （P=0. 005, OR=0. 421）, diabetic education （P=0.008, OR=4.031）, low educational level （P=0.014, OR=1.225） are factors of blood glucose by univariate analysis and multivariate Logistic regression analysis.